G.F. De Nicola

Mechanism and consequence of the autoactivation of p38α mitogen-activated protein kinase promoted by TAB1

G.F. De Nicola, Eva Denise Martin, A. Chaikuad et al. · Nature Structural & Molecular Biology · 2013 · 104 citations · Full text

Signal Transduction, Signaling Pathway, Biochemistry +9

Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein–Protein Inhibitors: Two Test Cases Illustrated by IL1β-IL1R and p38α–TAB1 Complexes

C. Blake Nichols, Joseph Ng, Annika Keshu et al. · Journal of Medicinal Chemistry · 2020 · 45 citations · Full text

X-ray Crystallography, Molecular Biology, Fragment Screens +22

TAB1-Induced Autoactivation of p38α Mitogen-Activated Protein Kinase Is Crucially Dependent on Threonine 185

Dibesh Thapa, C. Blake Nichols, Rekha Bassi et al. · Molecular and Cellular Biology · 2017 · 26 citations · Full text

The TAB1-p38α complex aggravates myocardial injury and can be targeted by small molecules

G.F. De Nicola, Rekha Bassi, C. Blake Nichols et al. · JCI Insight · 2018 · 23 citations · Full text

Cardiac Muscle, Heart Failure, Cell Death +25

Identification of I137M and Other Mutations That Modulate Incubation Periods for Two Human Prion Strains

Kurt Giles, G.F. De Nicola, Smita S. Patel et al. · Journal of Virology · 2012 · 14 citations · Full text