Dongyu Xue

DeepCRISPR: optimized CRISPR guide RNA design by deep learning

Guohui Chuai, Hanhui Ma, Jifang Yan et al. · Genome biology · 2018 · 551 citations · Full text

Single Guide Rna, Machine Learning, Engineering +18

A ‘new lease of life’: FnCpf1 possesses DNA cleavage activity for genome editing in human cells

Mengjun Tu, Lin Li, Xiubin He et al. · Nucleic Acids Research · 2017 · 133 citations · Full text

Chromatin, Genome Instability, Functional Genomics +15

Advances and challenges in deep generative models for de novo molecule generation

Dongyu Xue, Yukang Gong, Zhaoyi Yang et al. · Wiley Interdisciplinary Reviews Computational Molecular Science · 2018 · 86 citations

Engineering, Machine Learning, Deep Generative Models +17

FL-QSAR: a federated learning-based QSAR prototype for collaborative drug discovery

Shaoqi Chen, Dongyu Xue, Guohui Chuai et al. · Bioinformatics · 2020 · 82 citations

Structure-informed Language Models Are Protein Designers

Zaixiang Zheng, Yifan Deng, Dongyu Xue et al. · 2023 · 50 citations · Full text

Engineering, Structural Bioinformatics, Molecular Biology +17