Jeff Kucharski

Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor

Matthew R. Janes, Jingchuan Zhang, Lian‐Sheng Li et al. · Cell · 2018 · 1.2K citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +12

Selective Inhibition of Oncogenic KRAS Output with Small Molecules Targeting the Inactive State

Matthew P. Patricelli, Matthew R. Janes, Lian‐Sheng Li et al. · Cancer Discovery · 2016 · 754 citations · Full text

Medicine, Medicinal Chemistry, Oncology +17

Selective Inhibition of Phosphoinositide 3-Kinase p110α Preserves Lymphocyte Function*

Lomon So, Sung Su Yea, Jean Oak et al. · Journal of Biological Chemistry · 2012 · 63 citations · Full text

Life Sciences, Cell Biology, Immunology +10

2,5-Diaminopyrimidines and 3,5-disubstituted azapurines as inhibitors of glycogen synthase kinase-3 (GSK-3)

Christopher Lum, Jeff Kahl, Linda Kessler et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 26 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +9

Abstract B148: INK128 is a potent and selective TORC1/2 inhibitor with broad oral antitumor activity

Katayoun A. Jessen, Shunyou Wang, Linda Kessler et al. · Molecular Cancer Therapeutics · 2009 · 24 citations

Medicine, Cancer Biology, Oncology +13