Toll-Like Receptor 8-Mediated Reversal of CD4 ⁺ Regulatory T Cell Function

Guangyong Peng, Zhong Guo, Yukiko Kiniwa, +7

Science

T-regulatory CellImmune RegulationImmunologyRegulatory T CellsCd4+ Regulatory T +21

Tumor-Specific Human CD4+ Regulatory T Cells and Their Ligands

Helen Y. Wang, Dean A. Lee, Guangyong Peng, +5

Immunity

Cancer ImmunosurveillanceT-regulatory CellImmunologyTumor ImmunityRegulatory T Cells +7

Tumor-Infiltrating γδ T Cells Suppress T and Dendritic Cell Function via Mechanisms Controlled by a Unique Toll-like Receptor Signaling Pathway

Guangyong Peng, Helen Y. Wang, Weiyi Peng, +3

Immunity

Cancer ImmunosurveillanceAdaptive Immune SystemImmunologyTumor ImmunityDendritic Cell Function +9

CD8+ Foxp3+ Regulatory T Cells Mediate Immunosuppression in Prostate Cancer

Yukiko Kiniwa, Yoshihiro Miyahara, Helen Y. Wang, +6

Clinical Cancer Research

Tumor Microenvironments Direct the Recruitment and Expansion of Human Th17 Cells

Xinming Su, Jian Ye, Eddy C. Hsueh, +3

The Journal of Immunology

T-regulatory CellImmunologyBiological MicroenvironmentsImmunologic MechanismHuman Tils +16

Generation and regulation of human CD4 ⁺ IL-17-producing T cells in ovarian cancer

Yoshihiro Miyahara, Kunle Odunsi, Wenhao Chen, +3

Proceedings of the National Academy of Sciences

T-regulatory CellImmunologyImmune RegulationPathologyMemory Th17 Cells +15

Reprogramming lipid metabolism prevents effector T cell senescence and enhances tumor immunotherapy

Xia Liu, Celine L. Hartman, Lingyun Li, +12

Science Translational Medicine

TLR8-Mediated Metabolic Control of Human Treg Function: A Mechanistic Target for Cancer Immunotherapy

Lingyun Li, Xia Liu, Katherine L. Sanders, +9

Cell Metabolism

Cancer ImmunosurveillanceSignal TransductionTlr8-mediated Metabolic ControlT-regulatory CellImmunology +9

Regulatory T cells trigger effector T cell DNA damage and senescence caused by metabolic competition

Xia Liu, Wei Mo, Jian Ye, +5

Nature Communications

CD4+ and CD8+ T cells have opposing roles in breast cancer progression and outcome

Yi Huang, Chunling Ma, Qunyuan Zhang, +8

Oncotarget