Astrocytic interleukin-3 programs microglia and limits Alzheimer’s disease

Cameron S. McAlpine, Joseph Park, Ana Griciuc, +24

Nature

Neurodegenerative DiseasesAlzheimer's DiseaseLimits Alzheimer ’MedicineBrain-immune Interaction +5

M. tuberculosis Reprograms Hematopoietic Stem Cells to Limit Myelopoiesis and Impair Trained Immunity

Nargis Khan, Jeffrey Downey, Joaquín Sanz, +13

Cell

Brain motor and fear circuits regulate leukocytes during acute stress

Wolfram C. Poller, Jeffrey Downey, Agnes A. Mooslechner, +23

Nature

PsychoneuroimmunologyStress HormoneNeurophysiologyMedicineAffective Neuroscience +8

Monocytes re-enter the bone marrow during fasting and alter the host response to infection

Henrike Janssen, Florian Kahles, Dan Liu, +22

Immunity

InflammationHost ResponseGranulocyteHematologyImmunology +4

The heme-regulated inhibitor is a cytosolic sensor of protein misfolding that controls innate immune signaling

Mena Abdel‐Nour, Letícia A. M. Carneiro, Jeffrey Downey, +19

Science

NLRX1 prevents mitochondrial induced apoptosis and enhances macrophage antiviral immunity by interacting with influenza virus PB1-F2 protein

Joanna Jaworska, François Coulombe, Jeffrey Downey, +9

Proceedings of the National Academy of Sciences

Annexin1 regulates DC efferocytosis and cross-presentation during Mycobacterium tuberculosis infection

Fanny Tzelepis, Mark Verway, Jamal Ibrahim Daoud, +14

Journal of Clinical Investigation

Mycobacterium Tuberculosis InfectionImmunologyImmune RegulationMolecular BiologyImmunologic Mechanism +18

Sleep exerts lasting effects on hematopoietic stem cell function and diversity

Cameron S. McAlpine, Máté G. Kiss, Faris M. Zuraikat, +20

The Journal of Experimental Medicine

GeneticsAdult Stem CellImmunologyBlood CellEpigenetics +19

BCG immunization induces CX3CR1hi effector memory T cells to provide cross-protection via IFN-γ-mediated trained immunity

Kim A. Tran, Erwan Pernet, Mina Sadeghi, +7

Nature Immunology

AllergyTrained ImmunityAdaptive Immune SystemImmunologyImmunodominance +9

RIPK3 interacts with MAVS to regulate type I IFN-mediated immunity to Influenza A virus infection

Jeffrey Downey, Erwan Pernet, François Coulombe, +8

PLoS Pathogens