<i>Helicobacter pylori</i> HtrA is a new secreted virulence factor that cleaves E‐cadherin to disrupt intercellular adhesion

Benjamin Hoy, Martin Löwer, Christiane Weydig, +7

EMBO Reports

Protein FunctionSignal TransductionMicrobial PathogensIntercellular AdhesionVirulence Factor +7

Distinct Roles of Secreted HtrA Proteases from Gram-negative Pathogens in Cleaving the Junctional Protein and Tumor Suppressor E-cadherin

Benjamin Hoy, Tim Geppert, Manja Boehm, +8

Journal of Biological Chemistry

Protein SecretionProtein FunctionSignal TransductionMedicineSecreted Htra +10

Discovery of Small‐Molecule Interleukin‐2 Inhibitors from a DNA‐Encoded Chemical Library

Markus Leimbacher, Yixin Zhang, Luca Mannocci, +5

Chemistry - A European Journal

Context-Based Identification of Protein-Protein Interfaces and “Hot-Spot” Residues

Tim Geppert, Benjamin Hoy, Gisbert Schneider

Chemistry & Biology

BiochemistryProtein FoldingContext-based IdentificationNatural SciencesMolecular Biology +3

Inhibitors of Helicobacter pylori Protease HtrA Found by ‘Virtual Ligand’ Screening Combat Bacterial Invasion of Epithelia

Martin Löwer, Tim Geppert, Petra Schneider, +2

PLoS ONE

Reaction-Driven <i>De Novo</i> Design, Synthesis and Testing of Potential Type II Kinase Inhibitors

Gisbert Schneider, Tim Geppert, Markus Hartenfeller, +9

Future Medicinal Chemistry

Structural properties of so-called NSAID–phospholipid-complexes

Jan Hüsch, Bercem Dutagaci, Clemens Glaubitz, +11

European Journal of Pharmaceutical Sciences

Proteinlipid InteractionStructural PropertiesLipid BiophysicsBiochemistryMembrane Biology +3

Immunosuppressive Small Molecule Discovered by Structure‐Based Virtual Screening for Inhibitors of Protein–Protein Interactions

Tim Geppert, Stefanie Bauer, Jan A. Hiss, +8

Angewandte Chemie International Edition

Protein–protein InteractionsDrug TargetMolecular BiologyAntiviral DrugLead Compound +18

Homology Model Adjustment and Ligand Screening with a Pseudoreceptor of the Human Histamine H₄ Receptor

Yusuf Tanrıkulu, Ewgenij Proschak, Tim Werner, +10

ChemMedChem

Molecular BiologyMolecular PharmacologyScaffold HoppingHomology Model AdjustmentMolecular Recognition +16

Inhibiting Helicobacter pylori HtrA protease by addressing a computationally predicted allosteric ligand binding site

Anna Maria Perna, Felix Reisen, Thomas P. Schmidt, +7

Chemical Science