Kevin D. Rynearson

Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer’s Disease Neurons

Rik van der Kant, Vanessa F. Langness, Cheryl Herrera et al. · Cell stem cell · 2019 · 373 citations · Full text

Life Sciences, Biochemistry, Neuroscience +16

Nanopore-Based Conformational Analysis of a Viral RNA Drug Target

Carolyn Shasha, Robert Y. Henley, Daniel H. Stoloff et al. · ACS Nano · 2014 · 74 citations · Full text

Life Sciences, Biology, Molecular Biology +17

Preclinical validation of a potent γ-secretase modulator for Alzheimer’s disease prevention

Kevin D. Rynearson, Moorthi Ponnusamy, Olga Prikhodko et al. · The Journal of Experimental Medicine · 2021 · 72 citations · Full text

Medicine, Neuroscience, Pharmacology +17

Soluble γ-Secretase Modulators Selectively Inhibit the Production of the 42-Amino Acid Amyloid β Peptide Variant and Augment the Production of Multiple Carboxy-Truncated Amyloid β Species

Steven L. Wagner, Can Zhang, Soan Cheng et al. · Biochemistry · 2014 · 50 citations

Life Sciences, Neurology, Neuroscience +17

Pharmacological and Toxicological Properties of the Potent Oral γ-Secretase Modulator BPN-15606

Steven L. Wagner, Kevin D. Rynearson, Steven K. Duddy et al. · Journal of Pharmacology and Experimental Therapeutics · 2017 · 47 citations · Full text

Life Sciences, Neuroscience, Pharmacology +17