Margaret C. Cirtain

Essential features of the P-glycoprotein pharmacophore as defined by a series of reserpine analogs that modulate multidrug resistance.

Homer L. Pearce, Ahmad R. Safa, Nicholas J. Bach et al. · Proceedings of the National Academy of Sciences · 1989 · 234 citations · Full text

Drug Target, P-glycoprotein Pharmacophore, Pharmacotherapy +18

Altered catalytic activity of and DNA cleavage by DNA topoisomerase II from human leukemic cells selected for resistance to VM-26

Mary K. Danks, Carla Schmidt, Margaret C. Cirtain et al. · Biochemistry · 1988 · 221 citations

Pharmacological, molecular, and cytogenetic analysis of "atypical" multidrug-resistant human leukemic cells.

William T. Beck, Margaret C. Cirtain, Mary K. Danks et al. · PubMed · 1987 · 182 citations

Mdr Gene, Chemoprevention Strategy, Immunology +21

Effects of indole alkaloids on multidrug resistance and labeling of P-glycoprotein by a photoaffinity analog of vinblastine

William T. Beck, Margaret C. Cirtain, Constance J. Glover et al. · Biochemical and Biophysical Research Communications · 1988 · 113 citations

Drug Analysis, Biochemistry, Medicine +9

Reversal of Vinca alkaloid resistance but not multiple drug resistance in human leukemic cells by verapamil.

William T. Beck, Margaret C. Cirtain, AT Look et al. · PubMed · 1986 · 96 citations

Ca2+ Channel Blocker, Immunology, Pharmacotherapy +16