Human circulating influenza-CD4 ⁺ ICOS1 ⁺ IL-21 ⁺ T cells expand after vaccination, exert helper function, and predict antibody responses

Fabiana Spensieri, Erica Borgogni, Luisanna Zedda, +10

Proceedings of the National Academy of Sciences

Efficacy, immunogenicity, and safety of a parenteral vaccine against Helicobacter pylori in healthy volunteers challenged with a Cag-positive strain: a randomised, placebo-controlled phase 1/2 study

Peter Malfertheiner, Michael Selgrad, Thomas Wex, +14

˜The œLancet. Gastroenterology & hepatology

VaccinationParenteral VaccineInfection ControlCag-positive StrainMedicine +2

Surface layer proteins from Clostridium difficile induce inflammatory and regulatory cytokines in human monocytes and dendritic cells

Clara Maria Ausiello, Marina Cerquetti, Giorgio Fedele, +5

Microbes and Infection

InflammationSurface Layer ProteinsGranulocytePathogenesisImmunology +6

Bordetella pertussis Commits Human Dendritic Cells to Promote a Th1/Th17 Response through the Activity of Adenylate Cyclase Toxin and MAPK-Pathways

Giorgio Fedele, Fabiana Spensieri, Raffaella Palazzo, +4

PLoS ONE

B. Pertussis InfectionInnate Immune SystemImmunologyPathologyImmunologic Mechanism +17

IFN-γ Arms Human Dendritic Cells to Perform Multiple Effector Functions

Loredana Frasca, Maria Nasso, Fabiana Spensieri, +4

The Journal of Immunology

Lipopolysaccharides from <i>Bordetella pertussis</i> and <i>Bordetella parapertussis</i> Differently Modulate Human Dendritic Cell Functions Resulting in Divergent Prevalence of Th17-Polarized Responses

Giorgio Fedele, Maria Nasso, Fabiana Spensieri, +4

The Journal of Immunology

<i>Bordetella pertussis</i>-Infected Human Monocyte-Derived Dendritic Cells Undergo Maturation and Induce Th1 Polarization and Interleukin-23 Expression

Giorgio Fedele, Paola Stefanelli, Fabiana Spensieri, +3

Infection and Immunity

Genetically Detoxified Pertussis Toxin Induces Th1/Th17 Immune Response through MAPKs and IL-10-Dependent Mechanisms

Maria Nasso, Giorgio Fedele, Fabiana Spensieri, +4

The Journal of Immunology

Immune RegulationImmunologyPertussis ToxinInflammationImmunopathology +15

<i>Bordetella pertussis</i>Inhibition of Interleukin-12 (IL-12) p70 in Human Monocyte-Derived Dendritic Cells Blocks IL-12 p35 through Adenylate Cyclase Toxin-Dependent Cyclic AMP Induction

Fabiana Spensieri, Giorgio Fedele, Cecilia Fazio, +4

Infection and Immunity

Immune RegulationImmunologyImmunologic MechanismCd4 T Cell ResponsesInnate Immunity +17

Early Rise of Blood T Follicular Helper Cell Subsets and Baseline Immunity as Predictors of Persisting Late Functional Antibody Responses to Vaccination in Humans

Fabiana Spensieri, Emilio Siena, Erica Borgogni, +12

PLoS ONE

Adaptive Immune SystemHumoral ResponseImmunologyImmunodominanceCell Subsets +15