Virtual Ligand Screening of the p300/CBP Histone Acetyltransferase: Identification of a Selective Small Molecule Inhibitor

Erin M. Bowers, Gai Yan, Chandrani Mukherjee, +16

Chemistry & Biology

P300/cbp Histone AcetyltransferaseMedicinal ChemistryDrug TargetFunctional SelectivityNatural Sciences +6

ISWI chromatin remodellers sense nucleosome modifications to determine substrate preference

Geoffrey P. Dann, Glen Liszczak, John D. Bagert, +11

Nature

ChromatinTranscriptional RegulationIswi Chromatin RemodellersChromatin StructureChromatin Remodeling +11

Molecular basis for N-terminal acetylation by the heterodimeric NatA complex

Glen Liszczak, Jacob M. Goldberg, Håvard Foyn, +3

Nature Structural & Molecular Biology

Heterodimeric Nata ComplexBiochemistryNatural SciencesCoordination ComplexMolecular Biology +3

Biochemical and cellular analysis of Ogden syndrome reveals downstream Nt-acetylation defects

Line M. Myklebust, Petra Van Damme, Svein I. Støve, +14

Human Molecular Genetics

A two-state activation mechanism controls the histone methyltransferase Suv39h1

Manuel M. Müller, Beat Fierz, Lenka Bittova, +2

Nature Chemical Biology

Histone ModificationsChromatinChromatin StructureChromatin RemodelingNatural Sciences +9

Mutations linked to neurological disease enhance self-association of low-complexity protein sequences

Xiaoming Zhou, Lily Sumrow, Kyuto Tashiro, +6

Science

Low-complexity Protein SequencesProtein AssemblyGeneticsGenetic EpidemiologyMolecular Biology +25

Structure of a Ternary Naa50p (NAT5/SAN) N-terminal Acetyltransferase Complex Reveals the Molecular Basis for Substrate-specific Acetylation

Glen Liszczak, Thomas Arnesen, Ronen Marmorstein

Journal of Biological Chemistry

Substrate-specific AcetylationProtein AssemblyMolecular BiologyPeptide ScienceAnalytical Ultracentrifugation +15

Acetylation blocks DNA damage–induced chromatin ADP-ribosylation

Glen Liszczak, Katharine L. Diehl, Geoffrey P. Dann, +1

Nature Chemical Biology

ChromatinGenome InstabilityDna DamageChromatin StructureChromatin Remodeling +6

A basic motif anchoring ISWI to nucleosome acidic patch regulates nucleosome spacing

Hai T. Dao, Barbara E. Dul, Geoffrey P. Dann, +2

Nature Chemical Biology

ChromatinTranscriptional RegulationChromatin StructureChromatin RemodelingNatural Sciences +10

The Molecular Basis for Histone H4- and H2A-Specific Amino-Terminal Acetylation by NatD

Robert S. Magin, Glen Liszczak, Ronen Marmorstein

Structure

Histone ModificationsChromatinChromatin StructureBiochemistryChromatin Remodeling +11