Lakshmi Bhagavatula

Discovery, Structure−Activity Relationship, and Pharmacological Evaluation of (5-Substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as Potent Dipeptidyl Peptidase IV Inhibitors

Zhonghua Pei, Xiaofeng Li, Kenton L. Longenecker et al. · Journal of Medicinal Chemistry · 2006 · 61 citations · Full text

Medicinal Chemistry, Pharmaceutical Science, Biochemistry +14

Reduction of an Enaminone:  Synthesis of the Diamino Alcohol Core of Ritonavir

Anthony R. Haight, Timothy L. Stuk, M.S. Allen et al. · Organic Process Research & Development · 1999 · 54 citations

Two-step Reduction Sequence, Diamino Alcohol Core, Borane-sulfonate Derivative +7

Discovery of 2-[4-{{2-(2<i>S</i>,5<i>R</i>)-2-Cyano-5-ethynyl-1-pyrrolidinyl]-2-oxoethyl]amino]- 4-methyl-1-piperidinyl]-4-pyridinecarboxylic Acid (ABT-279):  A Very Potent, Selective, Effective, and Well-Tolerated Inhibitor of Dipeptidyl Peptidase-IV, Useful for the Treatment of Diabetes

David J. Madar, Hana Kopecka, Daisy Pireh et al. · Journal of Medicinal Chemistry · 2006 · 37 citations · Full text

A highly diastereoselective vinylogous Mannich condensation and 1,4-conjugate addition of (Z)-propenyl cuprate in the synthesis of an influenza neuraminidase inhibitor

David M. Barnes, Lakshmi Bhagavatula, John A. DeMattei et al. · Tetrahedron Asymmetry · 2003 · 36 citations

Medicinal Chemistry, Bioorganic Chemistry, Biochemistry +8

Synthesis of N-(Tert-butoxycarbonyl)-3-(4-thiazoIyl)-L-alanine

C.‐N. HSIAO, M. Robert Leanna, Lakshmi Bhagavatula et al. · Synthetic Communications · 1990 · 26 citations

Engineering, Organic Chemistry, Natural Product Synthesis +3