Sean M. DeGuire

N-terminal Huntingtin (Htt) phosphorylation is a molecular switch regulating Htt aggregation, helical conformation, internalization, and nuclear targeting

Sean M. DeGuire, Francesco Simone Ruggeri, Mohamed-Bilal Fares et al. · Journal of Biological Chemistry · 2018 · 89 citations · Full text

Phosphorylation of huntingtin at residue T3 is decreased in Huntington’s disease and modulates mutant huntingtin protein conformation

Cristina Cariulo, Lucia Azzollini, Margherita Verani et al. · Proceedings of the National Academy of Sciences · 2017 · 77 citations · Full text

Mutant Exon1 Huntingtin Aggregation is Regulated by T3 Phosphorylation‐Induced Structural Changes and Crosstalk between T3 Phosphorylation and Acetylation at K6

Anass Chiki, Sean M. DeGuire, Francesco Simone Ruggeri et al. · Angewandte Chemie International Edition · 2017 · 73 citations · Full text

Revisiting the specificity and ability of phospho-S129 antibodies to capture alpha-synuclein biochemical and pathological diversity

Hilal A. Lashuel, Anne‐Laure Mahul‐Mellier, Salvatore Novello et al. · npj Parkinson s Disease · 2022 · 63 citations · Full text

7-Azaindenoisoquinolines as Topoisomerase I Inhibitors and Potential Anticancer Agents

Evgeny Kiselev, Sean M. DeGuire, Andrew Morrell et al. · Journal of Medicinal Chemistry · 2011 · 61 citations