A2A adenosine receptor protects tumors from antitumor T cells

Akio Ohta, Elieser Gorelik, Simon J. Prasad, +12

Proceedings of the National Academy of Sciences

Cancer ImmunosurveillanceMedicineTumor GrowthA2 ReceptorsImmunology +10

Immunological mechanisms of the antitumor effects of supplemental oxygenation

Stephen Hatfield, Jørgen Kjaergäard, Dmitriy Lukashev, +15

Science Translational Medicine

Differential Effects of Physiologically Relevant Hypoxic Conditions on T Lymphocyte Development and Effector Functions

Charles C. Caldwell, Hidefumi Kojima, Dmitriy Lukashev, +4

The Journal of Immunology

Lymphocyte DevelopmentT-regulatory CellImmunologyImmune RegulationImmunologic Mechanism +20

Cutting Edge: Hypoxia-Inducible Factor 1α and Its Activation-Inducible Short Isoform I.1 Negatively Regulate Functions of CD4+ and CD8+ T Lymphocytes

Dmitriy Lukashev, Boris Klebanov, Hidefumi Kojima, +6

The Journal of Immunology

Systemic oxygenation weakens the hypoxia and hypoxia inducible factor 1α-dependent and extracellular adenosine-mediated tumor protection

Stephen Hatfield, Jørgen Kjaergäard, Dmitriy Lukashev, +15

Journal of Molecular Medicine

Systemic OxygenationOncologyMedicinePhysiologyHypoxia (Medicine) +10

Cutting Edge: Physiologic Attenuation of Proinflammatory Transcription by the Gs Protein-Coupled A2A Adenosine Receptor In Vivo

Dmitriy Lukashev, Akio Ohta, Sergey Apasov, +2

The Journal of Immunology

Inflammatory Lung DiseaseImmunologyImmune RegulationCell DeathImmunologic Mechanism +26

Regulated control of gene therapies by drug-induced splicing

Alex Mas Monteys, Amiel A. Hundley, Paul T. Ranum, +6

Nature

Gene TherapiesTranscriptional RegulationNovel TherapyRna SplicingGene Expression +4

An orally available, brain penetrant, small molecule lowers huntingtin levels by enhancing pseudoexon inclusion

Caroline Gubser Keller, Youngah Shin, Alex Mas Monteys, +18

Nature Communications

Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice

Almut Grenz, Jessica D. Bauerle, Julee H. Dalton, +23

Journal of Clinical Investigation

Differential Regulation of Two Alternatively Spliced Isoforms of Hypoxia-inducible Factor-1α in Activated T Lymphocytes

Dmitriy Lukashev, Charles C. Caldwell, Akio Ohta, +2

Journal of Biological Chemistry