Linda Campbell

Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis

Alan D. Irvine, Ana Terron-Kwiatkowski, Yiwei Zhao et al. · Nature Genetics · 2006 · 2.9K citations

Major Predisposing Factor, Common Loss-of-function Variants, Atopic Dermatitis +8

Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris

Frances J.D. Smith, Alan D. Irvine, Ana Terron-Kwiatkowski et al. · Nature Genetics · 2006 · 1K citations

Biology, Mendelian Disorder, Genetic Disorder +10

Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema

Aileen Sandilands, Ana Terron-Kwiatkowski, Peter Hull et al. · Nature Genetics · 2007 · 660 citations

Allergy, Atopic Dermatitis, Genetic Disorder +11

A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming

Padraic G. Fallon, Takashi Sasaki, Aileen Sandilands et al. · Nature Genetics · 2009 · 470 citations · Full text

Knockout Mouse, Allelic Variant, Developmental Biology +8

Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy

Sara Brown, Yuka Asai, Heather J. Cordell et al. · Journal of Allergy and Clinical Immunology · 2011 · 466 citations · Full text