Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease

Azeb Tadesse Argaw, Linnéa Asp, Jingya Zhang, +10

Journal of Clinical Investigation

Bbb PermeabilityImmunologyGliomaNeuroinflammationInflammation +17

Loss of CHD1 Promotes Heterogeneous Mechanisms of Resistance to AR-Targeted Therapy via Chromatin Dysregulation

Zeda Zhang, Chuanli Zhou, Xiaoling Li, +29

Cancer Cell

GeneticsChromatin DysregulationEpigeneticsAr-targeted TherapyRadiation Oncology +14

PITPNC1 Recruits RAB1B to the Golgi Network to Drive Malignant Secretion

Nils Halberg, C.A. Sengelaub, Kristina Navrazhina, +3

Cancer Cell

Tumor BiologyOncogenic AgentMedicinePitpnc1 Recruits Rab1bPathology +6

Epithelialized tunnels are a source of inflammation in hidradenitis suppurativa

Kristina Navrazhina, John W. Frew, Patricia Gilleaudeau, +3

Journal of Allergy and Clinical Immunology

InflammationAutoimmune DiseaseImmunologyWound HealingDermatology +4

Ipilimumab plus nivolumab for patients with metastatic uveal melanoma: a multicenter, retrospective study

Yana G. Najjar, Kristina Navrazhina, Fei Ding, +25

Journal for ImmunoTherapy of Cancer

<scp>PTPRN</scp> 2 and <scp>PLC</scp> β1 promote metastatic breast cancer cell migration through <scp>PI</scp> (4,5)P ₂ ‐dependent actin remodeling

C.A. Sengelaub, Kristina Navrazhina, Jason Ross, +2

The EMBO Journal

The effect of subcutaneous brodalumab on clinical disease activity in hidradenitis suppurativa: An open-label cohort study

John W. Frew, Kristina Navrazhina, David Grand, +5

Journal of the American Academy of Dermatology

InflammationRheumatologyClinical Disease ActivityClinical DermatologySubcutaneous Brodalumab +4

Hidradenitis suppurativa: new insights into disease mechanisms and an evolving treatment landscape

James G. Krueger, John W. Frew, Gregor B. E. Jemec, +8

British Journal of Dermatology

TGFβ1 induces Jagged1 expression in astrocytes via ALK5 and Smad3 and regulates the balance between oligodendrocyte progenitor proliferation and differentiation

Yueting Zhang, Jingya Zhang, Kristina Navrazhina, +5

Glia

Clinical response rates, placebo response rates, and significantly associated covariates are dependent on choice of outcome measure in hidradenitis suppurativa: A post hoc analysis of PIONEER 1 and 2 individual patient data

John W. Frew, Caroline S. Jiang, Neha Singh, +4

Journal of the American Academy of Dermatology

Clinical TrialsOutcomes ResearchPatient-reported OutcomePioneer 1Clinical Dermatology +4