Therapeutic inhibition of the miR-34 family attenuates pathological cardiac remodeling and improves heart function

Bianca C. Bernardo, Xiao-Ming Gao, Catherine E. Winbanks, +9

Proceedings of the National Academy of Sciences

Phosphoinositide 3-Kinase p110α Is a Master Regulator of Exercise-Induced Cardioprotection and PI3K Gene Therapy Rescues Cardiac Dysfunction

Kate L. Weeks, Xiao‐Ming Gao, Xiao‐Jun Du, +14

Circulation Heart Failure

The small-molecule BGP-15 protects against heart failure and atrial fibrillation in mice

Geeta Sapra, Yow Keat Tham, Nelly Cemerlang, +17

Nature Communications

CardiomyopathyHeart FailureMolecular PhysiologyCardiovascular DiseaseMedicine +10

Enhanced phosphoinositide 3-kinase(p110α) activity prevents diabetes-induced cardiomyopathy and superoxide generation in a mouse model of diabetes

Rebecca H. Ritchie, J. Love, K. Huynh, +11

Diabetologia

Superoxide GenerationMolecular PhysiologyMedicinePhysiologyDiabetes +8

Lipidomic Profiles of the Heart and Circulation in Response to Exercise versus Cardiac Pathology: A Resource of Potential Biomarkers and Drug Targets

Yow Keat Tham, Bianca C. Bernardo, Kevin Huynh, +6

Cell Reports

Heart FailurePotential BiomarkersCardiovascular FunctionCardiovascular ToxicityMetabolic Syndrome +14

Therapeutic silencing of miR‐652 restores heart function and attenuates adverse remodeling in a setting of established pathological hypertrophy

Bianca C. Bernardo, Sally Nguyen, Catherine E. Winbanks, +12

The FASEB Journal

Heart FailureCardiac RegenerationCardiovascular FunctionTherapeutic SilencingCardiology +16

Silencing of miR-34a Attenuates Cardiac Dysfunction in a Setting of Moderate, but Not Severe, Hypertrophic Cardiomyopathy

Bianca C. Bernardo, Xiao‐Ming Gao, Yow Keat Tham, +10

PLoS ONE

Heart FailureCardiac Progenitor CellsPathologyCardiac RegenerationCardiovascular Translational Research +20

Inhibition of miR-154 Protects Against Cardiac Dysfunction and Fibrosis in a Mouse Model of Pressure Overload

Bianca C. Bernardo, Sally Nguyen, Xiao‐Ming Gao, +9

Scientific Reports

Sex differences in response to miRNA‐34a therapy in mouse models of cardiac disease: identification of sex‐, disease‐ and treatment‐regulated miRNAs

Bianca C. Bernardo, Jenny Y. Y. Ooi, Aya Matsumoto, +8

The Journal of Physiology

FoxO1 is required for physiological cardiac hypertrophy induced by exercise but not by constitutively active PI3K

Kate L. Weeks, Yow Keat Tham, Yonali Alexander, +10

American Journal of Physiology-Heart and Circulatory Physiology