Angelina M. Santini

Pharmacokinetic and Pharmacodynamic Characterization of an Oral Lysophosphatidic Acid Type 1 Receptor-Selective Antagonist

J. S. Swaney, Charles W. Chapman, Lucia Correa et al. · Journal of Pharmacology and Experimental Therapeutics · 2010 · 126 citations

Medicine, Pharmacokinetics, Pharmacology +11

Overcoming Preclinical Safety Obstacles to Discover (<i>S</i>)-<i>N</i>-((1,2,3,5,6,7-Hexahydro-<i>s</i>-indacen-4-yl)carbamoyl)-6-(methylamino)-6,7-dihydro-5<i>H</i>-pyrazolo[5,1-<i>b</i>][1,3]oxazine-3-sulfonamide (GDC-2394): A Potent and Selective NLRP3 Inhibitor

Christopher McBride, Lynnie Trzoss, Davide Povero et al. · Journal of Medicinal Chemistry · 2022 · 73 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Identification of 4-(Aminomethyl)-6-(trifluoromethyl)-2-(phenoxy)pyridine Derivatives as Potent, Selective, and Orally Efficacious Inhibitors of the Copper-Dependent Amine Oxidase, Lysyl Oxidase-Like 2 (LOXL2)

Martin W. Rowbottom, Gretchen Bain, Imelda Calderon et al. · Journal of Medicinal Chemistry · 2017 · 69 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Structural Basis for Inhibition of Human Autotaxin by Four Potent Compounds with Distinct Modes of Binding

Adam J. Stein, Gretchen Bain, Pat Prodanovich et al. · Molecular Pharmacology · 2015 · 67 citations

Life Sciences, Biochemistry, Pharmacology +10

Selective Inhibition of Autotaxin Is Efficacious in Mouse Models of Liver Fibrosis

Gretchen Bain, Kristen E. Shannon, Fei Huang et al. · Journal of Pharmacology and Experimental Therapeutics · 2016 · 56 citations

Medicine, Pharmacokinetics, Pharmacology +16