Gard Nelson

Molecular dynamic simulation reveals E484K mutation enhances spike RBD-ACE2 affinity and the combination of E484K, K417N and N501Y mutations (501Y.V2 variant) induces conformational change greater than N501Y mutant alone, potentially resulting in an escape mutant

Gard Nelson, Oleksandr Buzko, Patricia Spilman et al. · 2021 · 215 citations · Full text

Biophysical Modeling, Immunology, Viral Pathogenesis +17

Specific interaction between coronavirus leader RNA and nucleocapsid protein

Stephen A. Stohlman, Ralph S. Baric, Gard Nelson et al. · Journal of Virology · 1988 · 200 citations · Full text

Virus Structure, Northwestern Blot Analysis, Viral Replication +12

Fast and flexible gpu accelerated binding free energy calculations within the amber molecular dynamics package

Daniel J. Mermelstein, Charles Lin, Gard Nelson et al. · Journal of Computational Chemistry · 2018 · 103 citations

Engineering, Amber 18, Molecular Biology +17

An ACE2 Triple Decoy that neutralizes SARS-CoV-2 shows enhanced affinity for virus variants

Shiho Tanaka, Gard Nelson, C. Anders Olson et al. · Scientific Reports · 2021 · 73 citations · Full text

Millisecond-scale molecular dynamics simulation of spike RBD structure reveals evolutionary adaption of SARS-CoV-2 to stably bind ACE2

Gard Nelson, Oleksandr Buzko, Aaron Bassett et al. · 2020 · 11 citations

Biophysical Modeling, Immunology, Viral Pathogenesis +20