Patricia Spilman

Molecular dynamic simulation reveals E484K mutation enhances spike RBD-ACE2 affinity and the combination of E484K, K417N and N501Y mutations (501Y.V2 variant) induces conformational change greater than N501Y mutant alone, potentially resulting in an escape mutant

Gard Nelson, Oleksandr Buzko, Patricia Spilman et al. · 2021 · 215 citations · Full text

Biophysical Modeling, Immunology, Viral Pathogenesis +17

IL-15 Superagonist NAI in BCG-Unresponsive Non–Muscle-Invasive Bladder Cancer

Karim Chamie, Sam S. Chang, Eugene V. Kramolowsky et al. · NEJM Evidence · 2022 · 136 citations

Graphene nanoplatelet and graphene oxide functionalization of face mask materials inhibits infectivity of trapped SARS-CoV-2

Flavio De Maio, Valentina Palmieri, Gabriele Babini et al. · iScience · 2021 · 85 citations · Full text

Engineering, Synthetic Virology, Biomedical Engineering +18

An ACE2 Triple Decoy that neutralizes SARS-CoV-2 shows enhanced affinity for virus variants

Shiho Tanaka, Gard Nelson, C. Anders Olson et al. · Scientific Reports · 2021 · 73 citations · Full text

The Neurodegeneration Sequence in Prion Diseases: Evidence from Functional, Morphological and Ultrastructural Studies of the GABAergic System

Essia Bouzamondo-Bernstein, Stephanie D. Hopkins, Patricia Spilman et al. · Journal of Neuropathology & Experimental Neurology · 2004 · 57 citations

Creutzfeldt-jakob Disease, Synaptic Transmission, Prion Disease +18