J. S. Shane Rountree

Synthesis and Biological Characterisation of Novel <i>N</i>‐Alkyl‐Deoxynojirimycin α‐Glucosidase Inhibitors

Amy J. Rawlings, Hannah Lomas, Adam W. Pilling et al. · ChemBioChem · 2009 · 77 citations

Biological Characterisation, Medicinal Chemistry, Biochemistry +12

Design, Synthesis, and Biological Evaluation of Enantiomeric β‐<i>N</i>‐Acetylhexosaminidase Inhibitors LABNAc and DABNAc as Potential Agents against Tay‐Sachs and Sandhoff Disease

J. S. Shane Rountree, Terry D. Butters, Mark R. Wormald et al. · ChemMedChem · 2009 · 66 citations

Pharmaceutical Science, Sandhoff Disease, Glycobiology +18

Identification and Structure-Guided Development of Pyrimidinone Based USP7 Inhibitors

C. O'Dowd, Matthew Helm, J. S. Shane Rountree et al. · ACS Medicinal Chemistry Letters · 2018 · 66 citations · Full text

Efficient synthesis from d-lyxonolactone of 2-acetamido-1,4-imino-1,2,4-trideoxy-l-arabinitol LABNAc, a potent pyrrolidine inhibitor of hexosaminidases

J. S. Shane Rountree, Terry D. Butters, Mark R. Wormald et al. · Tetrahedron Letters · 2007 · 31 citations

Medicinal Chemistry, Bioorganic Chemistry, Biochemistry +12

Synthesis of a Novel Polyhydroxylated Salicylic Acid Lactone Framework

J. S. Shane Rountree, Paul V. Murphy · Organic Letters · 2009 · 25 citations

Bioorganic Chemistry, Engineering, Biochemistry +9