MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells

Delphine Lemaçon, Jessica Jackson, Annabel Quinet, +8

Nature Communications

ATR inhibition disrupts rewired homologous recombination and fork protection pathways in PARP inhibitor-resistant BRCA-deficient cancer cells

Stephanie A. Yazinski, Valentine Comaills, Rémi Buisson, +13

Genes & Development

Replication Fork ProtectionGenome InstabilityHealth SciencesMedicineHomologous Recombination +13

PRP19 Transforms into a Sensor of RPA-ssDNA after DNA Damage and Drives ATR Activation via a Ubiquitin-Mediated Circuitry

Alexandre Maréchal, Ju-Mei Li, Xiao Ye Ji, +7

Molecular Cell

Genome InstabilityDna DamageNatural SciencesGeneticsUbiquitin-mediated Circuitry +7

Spartan/C1orf124, a Reader of PCNA Ubiquitylation and a Regulator of UV-Induced DNA Damage Response

Richard C. Centore, Stephanie A. Yazinski, Alice Tse, +1

Molecular Cell

ChromatinGenome InstabilityDna DamagePcna UbiquitylationBiochemistry +7

Glutaminase and poly(ADP-ribose) polymerase inhibitors suppress pyrimidine synthesis and VHL-deficient renal cancers

Arimichi Okazaki, Paulo A. Gameiro, Danos C. Christodoulou, +9

Journal of Clinical Investigation

Suppression of Genome Instability in pRB-Deficient Cells by Enhancement of Chromosome Cohesion

Amity L. Manning, Stephanie A. Yazinski, Brandon Nicolay, +3

Molecular Cell

ChromatinGenome InstabilityGeneticsChromosome BiologyMolecular Genetics +6

Multiphoton microscopy and microspectroscopy for diagnostics of inflammatory and neoplastic lung

Ina Pavlova, Kelly R. Hume, Stephanie A. Yazinski, +4

Journal of Biomedical Optics

EngineeringOncologic ImagingPathologyLung TissueTissue Imaging +15

CRISPR-based gene disruption and integration of high-avidity, WT1-specific T cell receptors improve antitumor T cell function

Eliana Ruggiero, Erica Carnevale, Aaron Prodeus, +28

Science Translational Medicine

The BRCA1-Interacting Protein Abraxas Is Required for Genomic Stability and Tumor Suppression

A. Pons Castillo, Atanu Paul, Baohua Sun, +9

Cell Reports

Multiphoton microscopy as a diagnostic imaging modality for lung cancer

Ina Pavlova, Kelly R. Hume, Stephanie A. Yazinski, +3

Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE

EngineeringMicroscopyBiomedical EngineeringTissue ImagingBiomedical Optic +14