Ets-1 is a negative regulator of Th17 differentiation

Jacques Moisan, Roland Grenningloh, Estelle Bettelli, +2

The Journal of Experimental Medicine

Chronic Asthma–induced Airway Remodeling Is Prevented by Toll-like Receptor-7/8 Ligand S28463

Pierre Camateros, Meiyo Tamaoka, Muhannad Hassan, +6

American Journal of Respiratory and Critical Care Medicine

Synthetic RORγ agonists regulate multiple pathways to enhance antitumor immunity

Xiao Hu, Xikui Liu, Jacques Moisan, +19

OncoImmunology

TLR7 ligand prevents allergen-induced airway hyperresponsiveness and eosinophilia in allergic asthma by a MYD88-dependent and MK2-independent pathway

Jacques Moisan, Pierre Camateros, Thusanth Thuraisingam, +9

American Journal of Physiology-Lung Cellular and Molecular Physiology

AsthmaLung InflammationAllergy MedicineImmunologyAllergen +16

<i>In Vitro</i> Priming of Adoptively Transferred T Cells with a RORγ Agonist Confers Durable Memory and Stemness <i>In Vivo</i>

Xiao Hu, Kinga Majchrzak, Xikui Liu, +6

Cancer Research

A Novel IL6 Antibody Sensitizes Multiple Tumor Types to Chemotherapy Including Trastuzumab-Resistant Tumors

Haihong Zhong, April Davis, Maria Ouzounova, +16

Cancer Research

Whole-Molecule Antibody Engineering: Generation of a High-Affinity Anti-IL-6 Antibody with Extended Pharmacokinetics

Donna K. Finch, Matthew A. Sleeman, Jacques Moisan, +21

Journal of Molecular Biology

Immunocytochemical TechniqueHigh-affinity Anti-il-6 AntibodyMedicineWhole-molecule Antibody EngineeringImmunology +7

Preclinical investigations and a first-in-human phase I trial of M4112, the first dual inhibitor of indoleamine 2,3-dioxygenase 1 and tryptophan 2,3-dioxygenase 2, in patients with advanced solid tumors

Aung Naing, Joseph P. Eder, Sarina A. Piha‐Paul, +8

Journal for ImmunoTherapy of Cancer

Discovery of LYC-55716: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor-γ (RORγ) Agonist for Use in Treating Cancer

Thomas D. Aicher, Chad A. Van Huis, Alexander R. Hurd, +23

Journal of Medicinal Chemistry

Delayed Cutaneous Wound Healing in Mice Lacking Solute Carrier 11a1 (Formerly Nramp1): Correlation with Decreased Expression of Secretory Leukocyte Protease Inhibitor

Thusanth Thuraisingam, Hakeem Sam, Jacques Moisan, +3

Journal of Investigative Dermatology

InflammationCutaneous BiologyDecreased ExpressionFormerly Nramp1Wound Care +6