Communication between Multiple Drug Binding Sites on P-glycoprotein

Catherine Martin, G. Berridge, Christopher F. Higgins, +3

Molecular Pharmacology

Pheophorbide a Is a Specific Probe for ABCG2 Function and Inhibition

Robert W. Robey, Kenneth Steadman, Orsolya Polgár, +4

Cancer Research

Pha TransportMolecular BiologyCellular PharmacologyCellular PhysiologyDrug Resistance +14

In vitro and in vivo reversal of P-glycoprotein-mediated multidrug resistance by a novel potent modulator, XR9576.

Prakash Mistry, Alistair Stewart, Wendy Dangerfield, +6

PubMed

PharmacotherapyTumor BiologyP-glycoprotein-mediated Multidrug ResistanceTranslational PharmacologyDrug Resistance +15

The relationships between glutathione, glutathione-S-transferase and cytotoxicity of platinum drugs and melphalan in eight human ovarian carcinoma cell lines

Prakash Mistry, LR Kelland, G Abel, +2

British Journal of Cancer

Oncogenic AgentMedicinePharmacologyPlatinum DrugsPathology +5

The molecular interaction of the high affinity reversal agent XR9576 with P‐glycoprotein

Catherine Martin, G. Berridge, Prakash Mistry, +3

British Journal of Pharmacology

Ammine/amine platinum(IV) dicarboxylates: a novel class of platinum complex exhibiting selective cytotoxicity to intrinsically cisplatin-resistant human ovarian carcinoma cell lines.

Lloyd R. Kelland, Barry A. Murrer, G Abel, +3

PubMed

Chemoprevention StrategyCisplatin-resistant Cell LinesSelective CytotoxicityTumor BiologyOvarian Cancer +14

Reduced drug accumulation as a major mechanism of acquired resistance to cisplatin in a human ovarian carcinoma cell line: circumvention studies using novel platinum (II) and (IV) ammine/amine complexes

Prakash Mistry, LR Kelland, G Abel

British Journal of Cancer

Novel PlatinumMedicinePharmacologyAmmine/amine ComplexesDrug Accumulation +6

Structure−Activity Relationships for Pyrido-, Imidazo-, Pyrazolo-, Pyrazino-, and Pyrrolophenazinecarboxamides as Topoisomerase-Targeted Anticancer Agents

Swarna A. Gamage, Julie A. Spicer, Gordon W. Rewcastle, +7

Journal of Medicinal Chemistry

Pharmaceutical SciencePharmacotherapyPharmaceutical ChemistryDrug ResistanceMedicinal Chemistry +14

Novel Angular Benzophenazines:  Dual Topoisomerase I and Topoisomerase II Inhibitors as Potential Anticancer Agents

Nigel Vicker, Luke Burgess, Irina Chuckowree, +15

Journal of Medicinal Chemistry

Medicinal ChemistryPharmaceutical ChemistryBioorganic ChemistryChemoprevention StrategyMedicine +13

Mechanism-related circumvention of acquired cis-diamminedichloroplatinum(II) resistance using two pairs of human ovarian carcinoma cell lines by ammine/amine platinum(IV) dicarboxylates.

Lloyd R. Kelland, Prakash Mistry, G Abel, +4

PubMed

Ammine/amine PlatinumCisplatin ResistanceOncologyCollateral SensitivityEndocrine-related Cancer +12