Simon Chell

Intrinsic resistance to the MEK1/2 inhibitor AZD6244 (ARRY‐142886) is associated with weak ERK1/2 signalling and/or strong PI3K signalling in colorectal cancer cell lines

Kathryn Balmanno, Simon Chell, Annette S. Gillings et al. · International Journal of Cancer · 2009 · 144 citations

Life Sciences, Cell Biology, Oncology +17

Increased EP4 Receptor Expression in Colorectal Cancer Progression Promotes Cell Growth and Anchorage Independence

Simon Chell, Ian R. Witherden, Richard R. Dobson et al. · Cancer Research · 2006 · 142 citations · Full text

Medicine, Cancer Biology, Oncology +15

Prostaglandin F₂_α stimulates motility and invasion in colorectal tumor cells

David Qualtrough, Abderrahmane Kaidi, Simon Chell et al. · International Journal of Cancer · 2007 · 71 citations · Full text

Medicine, Oncology, Pharmacology +12

Colorectal cancer cells with the BRAFV600E mutation are addicted to the ERK1/2 pathway for growth factor-independent survival and repression of BIM

Julie A. Wickenden, Hong Ri Jin, Mark Johnson et al. · Oncogene · 2008 · 66 citations · Full text

Medicine, Genetics, Oncology +17

Inhibition of COX‐2 with NS‐398 decreases colon cancer cell motility through blocking epidermal growth factor receptor transactivation: possibilities for combination therapy

N Masoodhu Banu, Andrea Buda, Simon Chell et al. · Cell Proliferation · 2007 · 37 citations

Medicine, Oncology, Pharmacology +16