Challice L. Bonifant

JS-K, a glutathione/glutathione S-transferase-activated nitric oxide donor of the diazeniumdiolate class with potent antineoplastic activity.

Paul J. Shami, Joseph E. Saavedra, Lai Y. Wang et al. · PubMed · 2003 · 161 citations

Bioorganic Chemistry, Chemoprevention Strategy, Nitric Oxide +22

Activation of p53-Dependent Growth Suppression in Human Cells by Mutations in PTEN or PIK3CA

Jung-Sik Kim, Carolyn Lee, Challice L. Bonifant et al. · Molecular and Cellular Biology · 2006 · 156 citations · Full text

Cell Regulation, Human Cells, Pten Deletion +13

Engineering CAR-NK cells to secrete IL-15 sustains their anti-AML functionality but is associated with systemic toxicities

Ilias Christodoulou, Won Jin Ho, Andrew Marple et al. · Journal for ImmunoTherapy of Cancer · 2021 · 147 citations · Full text

Antitumor Activity of JS-K [<i>O</i>²-(2,4-Dinitrophenyl) 1-[(4-Ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate] and Related <i>O</i>²-Aryl Diazeniumdiolates in Vitro and in Vivo

Paul J. Shami, Joseph E. Saavedra, Challice L. Bonifant et al. · Journal of Medicinal Chemistry · 2006 · 107 citations

The Secondary Amine/Nitric Oxide Complex Ion R₂N[N(O)NO]^- as Nucleophile and Leaving Group in S_NAr Reactions

Joseph E. Saavedra, Aloka Srinivasan, Challice L. Bonifant et al. · The Journal of Organic Chemistry · 2001 · 97 citations