Peter A. Wells

KIT kinase mutants show unique mechanisms of drug resistance to imatinib and sunitinib in gastrointestinal stromal tumor patients

K.S. Gajiwala, Joe C. Wu, James G. Christensen et al. · Proceedings of the National Academy of Sciences · 2009 · 380 citations · Full text

Kit Kinase Mutants, Cancer Biology, Tumor Biology +16

Axitinib effectively inhibits BCR-ABL1(T315I) with a distinct binding conformation

Tea Pemovska, Eric F. Johnson, Mika Kontro et al. · Nature · 2015 · 235 citations

Molecular Pharmacology, Drug Target, Medicine +6

Crystal Structure of a Novel Dimeric Form of NS5A Domain I Protein from Hepatitis C Virus

Robert A. Love, Oleg Brodsky, Michael J. Hickey et al. · Journal of Virology · 2009 · 230 citations · Full text

Crystal Structure, Viral Replication, Protein Assembly +16

Crystal Structure of the Herpes Simplex Virus 1 DNA Polymerase

Shenping Liu, John D. Knafels, Jeanne S. Chang et al. · Journal of Biological Chemistry · 2006 · 175 citations · Full text

Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A

Casey L. Quinlan, Stephen E. Kaiser, Ben Bolaños et al. · Nature Chemical Biology · 2017 · 128 citations

Biosynthesis, Biochemistry, Natural Sciences +6