Autophagy Is Required for Activation of Pancreatic Stellate Cells, Associated With Pancreatic Cancer Progression and Promotes Growth of Pancreatic Tumors in Mice

Sho Endo, Kohei Nakata, Kenoki Ohuchida, +18

Gastroenterology

Cell AutophagyMitophagyPancreatic Stellate CellsPancreatic CancerAutophagy +9

CD34+CD38+CD19+ as well as CD34+CD38−CD19+ cells are leukemia-initiating cells with self-renewal capacity in human B-precursor ALL

Yuan Kong, Shuro Yoshida, Yoriko Saito, +13

Leukemia

Human B-precursor AllHematological MalignancyLymphocyte DevelopmentImmune Cell DevelopmentMedicine +8

Polymorphic Sirpa is the genetic determinant for NOD-based mouse lines to achieve efficient human cell engraftment

Takuji Yamauchi, Katsuto Takenaka, Shingo Urata, +11

Blood

Inhibition of ERK1/2 in cancer-associated pancreatic stellate cells suppresses cancer–stromal interaction and metastasis

Zilong Yan, Kenoki Ohuchida, Shuang Fei, +16

Journal of Experimental & Clinical Cancer Research

Evaluation of purine utilization by<i>Lactobacillus gasseri</i>strains with potential to decrease the absorption of food-derived purines in the human intestine

N. Yamada, Chika Iwamoto, Hiroshi Kano, +4

Nucleosides Nucleotides & Nucleic Acids

Necroptosis in pancreatic cancer promotes cancer cell migration and invasion by release of CXCL5

Yohei Ando, Kenoki Ohuchida, Yoshiki Otsubo, +11

PLoS ONE

Neutrophil extracellular traps promote liver micrometastasis in pancreatic ductal adenocarcinoma via the activation of cancer‑associated fibroblasts

Shin Takesue, Kenoki Ohuchida, Tomohiko Shinkawa, +18

International Journal of Oncology

Tumor BiologyPancreatic CancerHepatologyNeutrophil Extracellular TrapsMedicine +13

Extra-pancreatic invasion induces lipolytic and fibrotic changes in the adipose microenvironment, with released fatty acids enhancing the invasiveness of pancreatic cancer cells

Takashi Okumura, Kenoki Ohuchida, Masafumi Sada, +16

Oncotarget

Metabolic SyndromePancreatic CancerFatty AcidsMedicineCancer Growth +13

Adipose tissue‐derived stromal cells are sources of cancer‐associated fibroblasts and enhance tumor progression by dense collagen matrix

Takashi Okumura, Kenoki Ohuchida, Shin Kibe, +18

International Journal of Cancer

Basement membrane destruction by pancreatic stellate cells leads to local invasion in pancreatic ductal adenocarcinoma

Kazuhiro Koikawa, Kenoki Ohuchida, Shin Kibe, +14

Cancer Letters

Cancer ResearchPancreatic CancerMedicinePathologyLocal Invasion +7