Oxidative stress–induced mitochondrial dysfunction drives inflammation and airway smooth muscle remodeling in patients with chronic obstructive pulmonary disease

Coen Wiegman, Charalambos Michaeloudes, Gulammehdi Haji, +23

Journal of Allergy and Clinical Immunology

IL-1α/IL-1R1 Expression in Chronic Obstructive Pulmonary Disease and Mechanistic Relevance to Smoke-Induced Neutrophilia in Mice

Fernando Botelho, Carla M. T. Bauer, Donna K. Finch, +16

PLoS ONE

Deep Sequencing of B Cell Receptor Repertoires From COVID-19 Patients Reveals Strong Convergent Immune Signatures

Jacob D. Galson, Sebastian Schaetzle, Rachael Bashford-Rogers, +18

Frontiers in Immunology

VaccinationAdaptive Immune SystemVaccine TargetHumoral ResponseImmunology +11

Rituximab causes a polarization of B cells that augments its therapeutic function in NK-cell–mediated antibody-dependent cellular cytotoxicity

Dominika Rudnicka, Anna Oszmiana, Donna K. Finch, +5

Blood

FPR-1 is an important regulator of neutrophil recruitment and a tissue-specific driver of pulmonary fibrosis

Jack Leslie, Ben Millar, Alicia del Carpio Pons, +19

JCI Insight

A randomised, placebo-controlled trial of anti–interleukin-1 receptor 1 monoclonal antibody MEDI8968 in chronic obstructive pulmonary disease

Peter M.A. Calverley, Sanjay Sethi, Michelle Dawson, +5

Respiratory Research

Heterogeneity within and between physician-diagnosed asthma and/or COPD: NOVELTY cohort

Helen K. Reddel, Jørgen Vestbo, Àlvar Agustí, +17

European Respiratory Journal

The Role of Interleukin-1 and Interleukin-18 in Pro-Inflammatory and Anti-Viral Responses to Rhinovirus in Primary Bronchial Epithelial Cells

Siân Piper, John Ferguson, Linda J. Kay, +5

PLoS ONE

AsthmaInflammatory Lung DiseaseLung InflammationInnate Immune SystemViral Pathogenesis +18

Metabolic re-patterning in COPD airway smooth muscle cells

Charalambos Michaeloudes, Chih‐Hsi S. Kuo, Gulam Haji, +5

European Respiratory Journal

A cytokine-neutralizing antibody as a structural mimetic of 2 receptor interactions

Christian Grütter, Trevor Wilkinson, Richard V. Turner, +6

Proceedings of the National Academy of Sciences

ImmunologyImmunodominanceImmunologic MechanismImmunotherapyReceptor Tyrosine Kinase +16