Pro-apoptotic cationic host defense peptides rich in lysine or arginine to reverse drug resistance by disrupting tumor cell membrane

Yuxuan Dai, Xingguang Cai, Wei Shi, +7

Amino Acids

MedicinePeptide LibraryPeptide EngineeringImmunologyPeptide Therapeutic +5

Exploration of novel pyrrolo[2,1-f][1,2,4]triazine derivatives with improved anticancer efficacy as dual inhibitors of c-Met/VEGFR-2

Wei Shi, Qiang Hao, Dandan Huang, +3

European Journal of Medicinal Chemistry

Medicinal ChemistryDual InhibitorsMedicineImproved Anticancer EfficacyPharmacological Agent +7

Synthesis and anti-cancer evaluation of folic acid-peptide- paclitaxel conjugates for addressing drug resistance

Yuxuan Dai, Xingguang Cai, Xinzhou Bi, +7

European Journal of Medicinal Chemistry

Medicinal ChemistryHealth SciencesPolymer-drug ConjugateMedicinePharmacotherapy +7

Design, synthesis, and biological evaluation of thieno[2,3-d]pyrimidine derivatives as novel dual c-Met and VEGFR-2 kinase inhibitors

Jieming Li, Weijie Gu, Xinzhou Bi, +5

Bioorganic & Medicinal Chemistry

Medicinal ChemistryBiochemistryMedicineNatural SciencesRational Drug Design +9

A novel HPQ-based turn-on fluorescent probe for detection of fluoride ions in living cells

Xinzhou Bi, Wuxiang Mao, Xiaowei Xu

Tetrahedron Letters

Fluorescence MicroscopyFluoride IonsBiochemistryMedicineBioanalysis +5

Design, synthesis and biological evaluation of novel 4,5-dihydro-[1,2,4]triazolo[4,3-f]pteridine derivatives as potential BRD4 inhibitors

Xinzhou Bi, Jieming Li, Jiuhui Li, +7

Bioorganic & Medicinal Chemistry

Combinatorial ChemistryMedicinal ChemistryDerivative (Chemistry)Bioorganic ChemistryPotential Brd4 Inhibitors +9

pH-Sensitive micelles with mitochondria-targeted and aggregation-induced emission characterization: synthesis, cytotoxicity and biological applications

Jieming Li, Yan Liu, Huilan Li, +6

Biomaterials Science

EngineeringChemoprevention StrategyPh-sensitive MicellesProtein NanoparticlesTumor Biology +20

Design, synthesis and evaluation of a novel series of inhibitors reversing P‐glycoprotein‐mediated multidrug resistance

Hesham Ghaleb, Huilan Li, Mutta Kairuki, +8

Chemical Biology & Drug Design

Cancer MdrPharmacotherapyPharmaceutical ChemistryDrug ResistanceMolecular Pharmacology +17

Design, synthesis and biological evaluation of novel tetrahydroisoquinoline derivatives as P-glycoprotein-mediated multidrug resistance inhibitors

Yang Gao, Wei Shi, Jian Cui, +6

Bioorganic & Medicinal Chemistry

Medicinal ChemistryPharmaceutical ScienceBiochemistryNovel Tetrahydroisoquinoline DerivativesMedicine +9

Novel glucagon- and OXM-based peptides acting through glucagon and GLP-1 receptors with body weight reduction and anti-diabetic properties

Xingguang Cai, Chengye Li, Jie Zhou, +10

Bioorganic Chemistry

Metabolic SyndromeBiochemistryMedicineOxm-based PeptidesDiabetes +7