S. P. S. Saini

Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor

Wen Xie, Mei-Fei Yeuh, Anna Radomińska‐Pandya et al. · Proceedings of the National Academy of Sciences · 2003 · 358 citations · Full text

A Novel Constitutive Androstane Receptor-Mediated and CYP3A-Independent Pathway of Bile Acid Detoxification

S. P. S. Saini, Junichiro Sonoda, Li Xu et al. · Molecular Pharmacology · 2004 · 245 citations

Activation of LXRs prevents bile acid toxicity and cholestasis in female mice

Hirdesh Uppal, S. P. S. Saini, Antonio Moschetta et al. · Hepatology · 2007 · 148 citations · Full text

Orphan Nuclear Receptor Pregnane X Receptor Sensitizes Oxidative Stress Responses in Transgenic Mice and Cancerous Cells

Haibiao Gong, Shivendra V. Singh, Sharda P. Singh et al. · Molecular Endocrinology · 2005 · 110 citations

Lipid Peroxidation, Cell Death, Transgenic Mice +17

Combined loss of orphan receptors PXR and CAR heightens sensitivity to toxic bile acids in mice

Hirdesh Uppal, David Toma, S. P. S. Saini et al. · Hepatology · 2005 · 107 citations

Pxr Null Mice, Lipid Peroxidation, Pathology +18