Autocrine TGF-β Signaling Maintains Tumorigenicity of Glioma-Initiating Cells through Sry-Related HMG-Box Factors

Hiroaki Ikushima, Tomoki Todo, Yasushi Ino, +3

Cell stem cell

Glioma-initiating CellsSry-related Hmg-box FactorsSignaling PathwayGliomaMedicine +7

Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses

S. Chiba, Hiroaki Ikushima, Hiroshi Ueki, +9

eLife

Dectin-1 OrchestratesImmunologyNk CellsImmunoeditingImmunologic Mechanism +19

Conditional ablation of HMGB1 in mice reveals its protective function against endotoxemia and bacterial infection

Hideyuki Yanai, Atsushi Matsuda, Jianbo An, +8

Proceedings of the National Academy of Sciences

Glioma-initiating Cells Retain Their Tumorigenicity through Integration of the Sox Axis and Oct4 Protein

Hiroaki Ikushima, Tomoki Todo, Yasushi Ino, +4

Journal of Biological Chemistry

Sox AxisStem Cell BiologyCancer BiologyGliomaTumor Biology +16

An Id-like molecule, HHM, is a synexpression group-restricted regulator of TGF-β signalling

Hiroaki Ikushima, Akiyoshi Komuro, Kazunobu Isogaya, +4

The EMBO Journal

Transcriptional RegulationSignal TransductionSignaling PathwayMolecular PathwayMolecular Regulation +10

RB1CC1 Protein Positively Regulates Transforming Growth Factor-β Signaling through the Modulation of Arkadia E3 Ubiquitin Ligase Activity

Daizo Koinuma, Masahiko Shinozaki, Yoshiko Nagano, +8

Journal of Biological Chemistry

Substrate SelectivityTgf-β-induced ExpressionTumor BiologyTranscriptional RegulationSignaling Pathway +17

Oligodendrocyte Transcription Factor 1 (Olig1) Is a Smad Cofactor Involved in Cell Motility Induced by Transforming Growth Factor-β

Mitsuyoshi Motizuki, Kazunobu Isogaya, Kunio Miyake, +5

Journal of Biological Chemistry

Growth Factor-βTranscriptional RegulationDevelopmental BiologyCell RegulationCell Signaling +10

Structure of a dominant‐negative helix‐loop‐helix transcriptional regulator suggests mechanisms of autoinhibition

Ryohei Ishii, Kazunobu Isogaya, Azusa Seto, +10

The EMBO Journal

Beneficial innate signaling interference for antibacterial responses by a Toll-like receptor–mediated enhancement of the MKP-IRF3 axis

Hideo Negishi, Kosuke Matsuki, Nobuyasu Endo, +18

Proceedings of the National Academy of Sciences

Crystallization and preliminary X-ray diffraction analysis of GCIP/HHM transcriptional regulator

Azusa Seto, Hiroaki Ikushima, Toshiyasu Suzuki, +7

Acta Crystallographica Section F Structural Biology and Crystallization Communications