Thomas E. Frederick

Designing small molecules to target cryptic pockets yields both positive and negative allosteric modulators

Kathryn M. Hart, Katelyn E. Moeder, Chris Ho et al. · PLoS ONE · 2017 · 75 citations · Full text

Drug Target, Molecular Biology, Chemical Biology +23

Prediction of New Stabilizing Mutations Based on Mechanistic Insights from Markov State Models

Maxwell I. Zimmerman, Kathryn M. Hart, Carrie A. Sibbald et al. · ACS Central Science · 2017 · 72 citations · Full text

Electron Cryo-microscopy Structure of Ebola Virus Nucleoprotein Reveals a Mechanism for Nucleocapsid-like Assembly

Zhaoming Su, Chao Wu, Liuqing Shi et al. · Cell · 2018 · 58 citations · Full text

Virus Structure, Viral Replication, Electron Cryo-microscopy Structure +8

The Cap-Snatching SFTSV Endonuclease Domain Is an Antiviral Target

Wenjie Wang, Woo-Jin Shin, Bojie Zhang et al. · Cell Reports · 2020 · 48 citations · Full text

Opening of a cryptic pocket in β-lactamase increases penicillinase activity

Catherine R. Knoverek, Upasana L. Mallimadugula, Sukrit Singh et al. · Proceedings of the National Academy of Sciences · 2021 · 38 citations · Full text