Circular DNA elements of chromosomal origin are common in healthy human somatic tissue

Henrik Devitt Møller, Marghoob Mohiyuddin, Iñigo Prada-Luengo, +9

Nature Communications

Lifelong physical activity is associated with promoter hypomethylation of genes involved in metabolism, myogenesis, contractile properties and oxidative stress resistance in aged human skeletal muscle

M. Reza Sailani, Jens Frey Halling, Henrik Devitt Møller, +5

Scientific Reports

Exercise training protects against aging-induced mitochondrial fragmentation in mouse skeletal muscle in a PGC-1α dependent manner

Jens Frey Halling, Stine Ringholm, Jesper Olesen, +2

Experimental Gerontology

Muscle FunctionKinesiologyMitochondrial FunctionExercise Training ProtectsExercise +13

PGC-1α regulates mitochondrial properties beyond biogenesis with aging and exercise training

Jens Frey Halling, Henrik Jessen, Jacob Nøhr-Meldgaard, +7

American Journal of Physiology-Endocrinology and Metabolism

Mitochondrial PropertiesMitochondrial BiologyImpaired Mitochondrial FunctionMetabolic RemodelingRedox Biology +15

Effect of lifelong resveratrol supplementation and exercise training on skeletal muscle oxidative capacity in aging mice; impact of PGC-1α

Stine Ringholm, Jes Olesen, Jesper Thorhauge Pedersen, +5

Experimental Gerontology

Exercise TrainingLifelong Resveratrol SupplementationKinesiologyAgingExercise +10

PGC-1<i>α</i>promotes exercise-induced autophagy in mouse skeletal muscle

Jens Frey Halling, Stine Ringholm, Maja Munk Nielsen, +2

Physiological Reports

MitophagyLox/lox ControlCellular PhysiologyOxidative StressCell Autophagy +19

Regulation of apoptosis and autophagy in mouse and human skeletal muscle with aging and lifelong exercise training

Maja Munk Dethlefsen, Jens Frey Halling, Henrik Devitt Møller, +4

Experimental Gerontology

Cell AutophagyMitophagyLifelong Exercise TrainingKinesiologyAging +13

Inducible deletion of skeletal muscle AMPKα reveals that AMPK is required for nucleotide balance but dispensable for muscle glucose uptake and fat oxidation during exercise

Janne R. Hingst, Rasmus Kjøbsted, Jesper B. Birk, +19

Molecular Metabolism

Impact of Aging and Lifelong Exercise Training on Mitochondrial Function and Network Connectivity in Human Skeletal Muscle

Stine Ringholm, Anders Gudiksen, Jens Frey Halling, +5

The Journals of Gerontology Series A

Muscle FunctionAgingMitochondrial VolumeBiogerontologyLifelong Exercise Training +16

Role of PGC-1α in exercise training- and resveratrol-induced prevention of age-associated inflammation

Jes Olesen, Stine Ringholm, Maja Munk Nielsen, +5

Experimental Gerontology

InflammationMetabolic SyndromeAnti-inflammatoryAgingExercise +11