Torben Højland

A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity

Jesper B. Bramsen, Maria Bach Laursen, A. Nielsen et al. · Nucleic Acids Research · 2009 · 353 citations · Full text

Life Sciences, Biotechnology, Molecular Biology +17

Filling the gap in LNAantisense oligo gapmers: the effects of unlocked nucleic acid (UNA) and 4′- <i>C</i> -hydroxymethyl-DNA modifications on RNase H recruitment and efficacy of an LNA gapmer

Kees Fluiter, Olaf R.F. Mook, Jeroen Vreijling et al. · Molecular BioSystems · 2009 · 44 citations

Life Sciences, Biotechnology, Molecular Biology +12

LNA (locked nucleic acid) and analogs as triplex-forming oligonucleotides

Torben Højland, Surender Kumar, B. Ravindra Babu et al. · Organic & Biomolecular Chemistry · 2007 · 42 citations

Life Sciences, Biochemistry, Molecular Biology +16

DNA-selective hybridization and dual strand invasion of short double-stranded DNA using pyren-1-ylcarbonyl-functionalized 4′-C-piperazinomethyl-DNA

Torsten Bryld, Torben Højland, Jesper Wengel · Chemical Communications · 2004 · 39 citations

Life Sciences, Biotechnology, Molecular Biology +17

Computational Investigation of Locked Nucleic Acid (LNA) Nucleotides in the Active Sites of DNA Polymerases by Molecular Docking Simulations

Vasanthanathan Poongavanam, Praveen K. Madala, Torben Højland et al. · PLoS ONE · 2014 · 10 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17