Orest Hurko

MELAS mutation in mtDNA binding site for transcription termination factor causes defects in protein synthesis and in respiration but no change in levels of upstream and downstream mature transcripts.

Anne Chomyn, Andrea Martinuzzi, Makoto Yoneda et al. · Proceedings of the National Academy of Sciences · 1992 · 497 citations

Life Sciences, Molecular Biology, Molecular Genetics +17

Marked replicative advantage of human mtDNA carrying a point mutation that causes the MELAS encephalomyopathy.

Makoto Yoneda, Anne Chomyn, Andrea Martinuzzi et al. · Proceedings of the National Academy of Sciences · 1992 · 292 citations

Life Sciences, Genetics, Molecular Biology +16

Schizophrenia-Related Neural and Behavioral Phenotypes in Transgenic Mice Expressing Truncated<i>Disc1</i>

Sanbing Shen, Bing Lang, Chizu Nakamoto et al. · Journal of Neuroscience · 2008 · 254 citations · Full text

Life Sciences, Genetics, Neuroscience +17

Family study and segregation analysis of Tourette syndrome: evidence for a mixed model of inheritance.

John T. Walkup, M. C. Labuda, Harvey S. Singer et al. · PubMed · 1996 · 205 citations

Life Sciences, Genetics, Psychiatry +15

Respiration and Growth Defects in Transmitochondrial Cell Lines Carrying the 11778 Mutation Associated with Leber's Hereditary Optic Neuropathy

Götz Hofhaus, Donald R. Johns, Orest Hurko et al. · Journal of Biological Chemistry · 1996 · 162 citations · Full text

Life Sciences, Genetics, Molecular Biology +17