Sikai Ling

Targeting herpes simplex virus with CRISPR–Cas9 cures herpetic stromal keratitis in mice

Di Yin, Sikai Ling, Dawei Wang et al. · Nature Biotechnology · 2021 · 182 citations · Full text

Life Sciences, Molecular Biology, Molecular Genetics +12

Lentiviral delivery of co-packaged Cas9 mRNA and a Vegfa-targeting guide RNA prevents wet age-related macular degeneration in mice

Sikai Ling, Shiqi Yang, Xinde Hu et al. · Nature Biomedical Engineering · 2021 · 174 citations

Medicine, Genetics, Ophthalmology +16

Dendritic-cell-targeting virus-like particles as potent mRNA vaccine carriers

Di Yin, Yiye Zhong, Sikai Ling et al. · Nature Biomedical Engineering · 2024 · 93 citations

Pharmacy, Immunology, Molecular Pharmaceutics +14

Modified lentiviral globin gene therapy for pediatric β0/β0 transfusion-dependent β-thalassemia: A single-center, single-arm pilot trial

Shiqi Li, Sikai Ling, Dawei Wang et al. · Cell stem cell · 2024 · 77 citations

Medicine, Hematology, Pediatrics +14

Customizable virus-like particles deliver CRISPR–Cas9 ribonucleoprotein for effective ocular neovascular and Huntington’s disease gene therapy

Sikai Ling, Xue Zhang, Yao Dai et al. · Nature Nanotechnology · 2025 · 68 citations · Full text

Life Sciences, Biotechnology, Molecular Medicine +17