Jon K. Bowden-Verhoek

Optimization of novel reversible Bruton’s tyrosine kinase inhibitors identified using Tethering-fragment-based screens

Brian T. Hopkins, Eris Bame, Noah Bell et al. · Bioorganic & Medicinal Chemistry · 2019 · 15 citations · Full text

Molecular Docking, Molecular Pharmacology, Biochemistry +10

NPT520-34 improves neuropathology and motor deficits in a transgenic mouse model of Parkinson’s disease

Asma Khan, Robert Johnson, Carrie Wittmer et al. · Brain · 2021 · 15 citations · Full text

Line 61, Immunology, Cell Death +23

Utilizing structure based drug design and metabolic soft spot identification to optimize the in vitro potency and in vivo pharmacokinetic properties leading to the discovery of novel reversible Bruton’s tyrosine kinase inhibitors

Brian T. Hopkins, Eris Bame, Noah Bell et al. · Bioorganic & Medicinal Chemistry · 2021 · 11 citations · Full text

NPT1220-312, a TLR2/TLR9 Small Molecule Antagonist, Inhibits Pro-Inflammatory Signaling, Cytokine Release, and NLRP3 Inflammasome Activation

Agata Habas, Srinivasa Reddy Natala, Jon K. Bowden-Verhoek et al. · International Journal of Inflammation · 2022 · 10 citations · Full text