Z Chen

In vitro studies on cellular and molecular mechanisms of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia: As2O3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RAR alpha/PML proteins

G-Q Chen, Jing Zhu, XG Shi et al. · Blood · 1996 · 849 citations · Full text

Apoptosis and Growth Inhibition in Malignant Lymphocytes After Treatment With Arsenic Trioxide at Clinically Achievable Concentrations

Xinhua Zhu, Y. Shen, Yongkui Jing et al. · JNCI Journal of the National Cancer Institute · 1999 · 274 citations · Full text

Arsenic trioxide-induced apoptosis and differentiation are associated respectively with mitochondrial transmembrane potential collapse and retinoic acid signaling pathways in acute promyelocytic leukemia

Xun Cai, Y-L Shen, Qian Zhu et al. · Leukemia · 2000 · 259 citations

Mitophagy, Arsenic Trioxide-induced Apoptosis, Mitochondrial Function +10

Studies on the clinical efficacy and pharmacokinetics of low-dose arsenic trioxide in the treatment of relapsed acute promyelocytic leukemia: a comparison with conventional dosage

Yang Shen, Z-X Shen, Hong-Min Yan et al. · Leukemia · 2001 · 147 citations

Hematological Malignancy, Health Sciences, Medicine +8

Cobalt chloride and low oxygen tension trigger differentiation of acute myeloid leukemic cells: possible mediation of hypoxia-inducible factor-1α

Yijun Huang, K-M Du, Z-H Xue et al. · Leukemia · 2003 · 103 citations · Full text

Hematological Malignancy, Hypoxia (Medicine), Immunology +9