GPCRdb: an information system for G protein-coupled receptors

Vignir Ísberg, Stefan Mordalski, Christian Munk, +7

Nucleic Acids Research

EngineeringBiomolecular Structure PredictionMolecular BiologyGpcr DatabaseNew Features +14

GPCRdb in 2018: adding GPCR structure models and ligands

Gáspár Pándy‐Szekeres, Christian Munk, Tsonko M. Tsonkov, +5

Nucleic Acids Research

BioinformaticsMolecular RecognitionDrug TargetEngineeringG Protein-coupled Receptor +13

Structural insights into the lipid and ligand regulation of serotonin receptors

Peiyu Xu, Sijie Huang, Huibing Zhang, +16

Nature

Signal TransductionBiochemistryG Protein-coupled ReceptorMedicineNeurotransmitter +7

5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology

Yao Peng, John D. McCorvy, Kasper Harpsøe, +23

Cell

Molecular PharmacologyDrug TargetSignal TransductionG Protein-coupled ReceptorMedicine +7

GPCRs steer Gi and Gs selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors

Sijie Huang, Peiyu Xu, Dandan Shen, +13

Molecular Cell

Signal TransductionG Protein-coupled ReceptorMedicineFunctional SelectivitySerotonin Receptors +8

Total synthesis and structure–activity relationship studies of a series of selective G protein inhibitors

Xiao‐Feng Xiong, Hang Zhang, Christina Rye Underwood, +7

Nature Chemistry

Molecular PharmacologyBiochemistryMedicineRational Drug DesignTotal Synthesis +5

Structural Proof of a Dimeric Positive Modulator Bridging Two Identical AMPA Receptor-Binding Sites

Birgitte H. Kaae, Kasper Harpsøe, J.S. Kastrup, +8

Chemistry & Biology

Signal TransductionMolecular PhysiologyBiochemistryG Protein-coupled ReceptorNatural Sciences +8

Rational Design of α-Conotoxin Analogues Targeting α7 Nicotinic Acetylcholine Receptors

Christopher J. Armishaw, Anders A. Jensen, Thomas Balle, +5

Journal of Biological Chemistry

Intersubunit Bridge Formation Governs Agonist Efficacy at Nicotinic Acetylcholine α4β2 Receptors

L.A.H. Rohde, Philip K. Ahring, Marianne L. Jensen, +8

Journal of Biological Chemistry

Molecular PharmacologyMedicineSynaptic TransmissionNeurotransmitterNicotine +4

Development of a human vasopressin V1a-receptor antagonist from an evolutionary-related insect neuropeptide

Maria Giulia Di Giglio, Markus Muttenthaler, Kasper Harpsøe, +11

Scientific Reports