Early Pharmacotherapy Restores Neurogenesis and Cognitive Performance in the Ts65Dn Mouse Model for Down Syndrome

Patrizia Bianchi, Elisabetta Ciani, Sandra Guidi, +7

Journal of Neuroscience

Down SyndromeDevelopmental BiologyTs65dn Mouse ModelCognitive PerformancePsychiatry +12

DNMT3B interacts with constitutive centromere protein CENP-C to modulate DNA methylation and the histone code at centromeric regions

Suhasni Gopalakrishnan, Beth A. Sullivan, Stefania Trazzi, +2

Human Molecular Genetics

Loss of CDKL5 impairs survival and dendritic growth of newborn neurons by altering AKT/GSK-3β signaling

Claudia Fuchs, Stefania Trazzi, Roberta Torricella, +7

Neurobiology of Disease

APP-dependent up-regulation of Ptch1 underlies proliferation impairment of neural precursors in Down syndrome

Stefania Trazzi, Valentina Maria Mitrugno, Emanuele Valli, +6

Human Molecular Genetics

Brain DevelopmentSonic HedgehogSocial SciencesSignaling PathwayNeural Precursors +20

HDAC4: a key factor underlying brain developmental alterations in CDKL5 disorder

Stefania Trazzi, Claudia Fuchs, Rocchina Viggiano, +9

Human Molecular Genetics

Brain DevelopmentGeneticsHdac4 ActivityCdkl5 DisorderEpigenetics +17

CENP-C binds the alpha-satellite DNA in vivo at specific centromere domains

Valeria Politi, Giovanni Perini, Stefania Trazzi, +4

Journal of Cell Science

CB1 Cannabinoid Receptors Increase Neuronal Precursor Proliferation through AKT/Glycogen Synthase Kinase-3β/β-Catenin Signaling

Stefania Trazzi, Martin Steger, Valentina Maria Mitrugno, +2

Journal of Biological Chemistry

The C-Terminal Domain of CENP-C Displays Multiple and Critical Functions for Mammalian Centromere Formation

Stefania Trazzi, Giovanni Perini, Roberto Bernardoni, +3

PLoS ONE

Cenp-c Displays MultipleMolecular BiologyHuman Cenp-cCell CycleCell Regulation +15

Short- and long-term effects of neonatal pharmacotherapy with epigallocatechin-3-gallate on hippocampal development in the Ts65Dn mouse model of Down syndrome

Fiorenza Stagni, Andrea Giacomini, Marco Emili, +6

Neuroscience

Down SyndromeDevelopmental BiologyTs65dn Mouse ModelBrain DevelopmentMedicine +9

CDKL5 protein substitution therapy rescues neurological phenotypes of a mouse model of CDKL5 disorder

Stefania Trazzi, Marianna De Franceschi, Claudia Fuchs, +12

Human Molecular Genetics