(<i>S</i>)-(+)-4-[7-(2,2-Dimethyl-1-oxopro- poxy)-4-methyl-2-[4-[2-(1-piperidinyl)- ethoxy]phenyl]-2<i>H</i>-1-benzopyran-3-yl]- phenyl 2,2-Dimethylpropanoate (EM-800):  A Highly Potent, Specific, and Orally Active Nonsteroidal Antiestrogen

Sylvain Gauthier, Brigitte Caron, Julie Cloutier, +13

Journal of Medicinal Chemistry

Pharmaceutical ScienceAltmetric Attention ScoreOrganic ChemistryPharmacotherapyHeterocycle Chemistry +16

Regulation of Progesterone-Binding Breast Cyst Protein GCDFP-24 Secretion by Estrogens and Androgens in Human Breast Cancer Cells: A New Marker of Steroid Action in Breast Cancer*

Jacques Simard, Sophie Dauvois, Darrow E. Haagensen, +3

Endocrinology

Age-related changes in central nervous system enkephalins and substance P

A. Dupont, Pierre Savard, Yves Mérand, +2

Life Sciences

AgingNeurophysiologyNeuroanatomyPhysiologySocial Sciences +7

Changes in the β-endorphin content of discrete hypothalamic nuclei during the estrous cycle of the rat

Nicholas Barden, Yves Mérand, Dominique M. Rouleau, +2

Brain Research

Endocrine MechanismHypothalamusDiscrete Hypothalamic NucleiPhysiologyβ-Endorphin Content +9

Antiestrogenic properties of keoxifene,trans-4-hydroxytamoxifen, and ICI 164384, a new steroidal antiestrogen, in ZR-75-1 human breast cancer cells

Richard Poulin, Yves Mérand, Donald Poirier, +3

Breast Cancer Research and Treatment

Breast OncologyOncologyAntiestrogenic PropertiesMedicineGynecology +8

beta-Endorphin and met-enkephalins: their distribution, modulation by estrogens and haloperidol, and role in neuroendocrine control.

A. Dupont, Nicholas Barden, L. Cusan, +3

PubMed

Plasma ProlactinNeuroendocrinologyPrl ReleasePharmacotherapyExperimental Pharmacology +18

Synthesis and biological activity of new halo-steroidal antiestrogens

Charles Lévesque, Yves Mérand, Jean-Marc Dufour, +2

Journal of Medicinal Chemistry

Novel compounds inhibit estrogen formation and action.

Claude Labrie, Céline Martel, J. Dufour, +3

PubMed

Molecular PharmacologyMedicinal ChemistryEstrogen FormationInhibit Estrogen FormationMedicine +9

Characterization of the effects of the novel non-steroidal antiestrogen EM-800 on basal and estrogen-induced proliferation of T-47D, ZR-75-1 and MCF-7 human breast cancer cellsin vitro

Jacques Simard, Claude Labrie, Alain Bélanger, +4

International Journal of Cancer

Additive inhibitory effects of an androgen and the antiestrogen EM-170 on estradiol-stimulated growth of human ZR-75-1 breast tumors in athymic mice.

Sophie Dauvois, Chang-Shan Geng, Charles Lévesque, +2

PubMed

Breast OncologyEstradiol-stimulated GrowthGynecologyPharmacotherapyAntiestrogen Em-170 +17