Telavancin, a Multifunctional Lipoglycopeptide, Disrupts both Cell Wall Synthesis and Cell Membrane Integrity in Methicillin-Resistant <i>Staphylococcus aureus</i>

Deborah L. Higgins, Ray Chang, Dmitri Debabov, +12

Antimicrobial Agents and Chemotherapy

Microbial PathogensAntibacterial ActivityAntimicrobial ChemotherapyTelavancin ResultsBacterial Pathogens +20

A potent nonpeptide cholecystokinin antagonist selective for peripheral tissues isolated from Aspergillus alliaceus

Ray Chang, Virginia Lotti, Richard L. Monaghan, +8

Science

Gastrointestinal PharmacologyAntibiotic AdjuvantImmunologyGastroenterologyGallbladder Cck Receptors +16

A role for the melanocortin 4 receptor in sexual function

Lex H.T. Van der Ploeg, William J. Martin, Andrew D. Howard, +31

Proceedings of the National Academy of Sciences

Erectile DysfunctionFood IntakeReproductive BiologySocial SciencesHypothalamic Peptide +20

5-HT4 receptor agonist mediated enhancement of cognitive function in vivo and amyloid precursor protein processing in vitro: A pharmacodynamic and pharmacokinetic assessment

Fei Shen, Jacqueline A.M. Smith, Ray Chang, +4

Neuropharmacology

Neurodegenerative DiseasesAlzheimer's Disease5-Ht4 Receptor AgonistMedicineNeurochemical Biomarkers +6

Comparison of the Pharmacological Properties of Rat Na_V1.8 with Rat Na_V1.2a and Human Na_V1.5 Voltage-Gated Sodium Channel Subtypes Using a Membrane Potential Sensitive Dye and FLIPR^R

R. Vickery, Shanti M. Amagasu, Ray Chang, +7

Receptors and Channels

Synaptic TransmissionPlate ReaderExperimental PharmacologyCellular PhysiologySocial Sciences +15

Influence of ligand binding kinetics on functional inhibition of human recombinant serotonin and norepinephrine transporters

Pamela R. Tsuruda, Joey Yung, William J. Martin, +3

Journal of Pharmacological and Toxicological Methods

Human Recombinant SerotoninBiochemistryFunctional InhibitionMedicineNeurotransmitter +4

Comparison of the Pharmacological Properties of Rat NaV1.8 with Rat NaV1.2a and Human NaV1.5 Voltage-Gated Sodium Channel Subtypes Using a Membrane Potential Sensitive Dye and FLIPRR

R. Vickery, Shanti M. Amagasu, Ray Chang, +8

Receptors and Channels

Synaptic TransmissionNeurotransmitterAnesthetic MechanismPlate ReaderExperimental Pharmacology +22

Binding modes of dihydroquinoxalinones in a homology model of bradykinin receptor 1

Sookhee Ha, Pat J. Hey, Rick W. Ransom, +9

Biochemical and Biophysical Research Communications

Bradykinin Receptor 1Homology ModelBiochemistryG Protein-coupled ReceptorNatural Sciences +8

Identification of the Critical Residues of Bradykinin Receptor B1 for Interaction with the Kinins Guided by Site-Directed Mutagenesis and Molecular Modeling

Sookhee Ha, Pat J. Hey, Rick W. Ransom, +7

Biochemistry

Molecular BiologyCritical ResiduesB1 BradykininCell SignalingSite-directed Mutagenesis +19

Evidence for a Multivalent Interaction of Symmetrical, N-Linked, Lidocaine Dimers with Voltage-Gated Na+ Channels

Jacqueline A.M. Smith, Shanti M. Amagasu, J. Hembrador, +9

Molecular Pharmacology