Jean Dam

Synthesis of copper and zinc 2-(pyridin-2-yl)imidazo[1,2-a]pyridine complexes and their potential anticancer activity

Jean Dam, Zeenat Ismail, Taurai Kurebwa et al. · European Journal of Medicinal Chemistry · 2016 · 83 citations

Natural Sciences, Chemistry, Medicinal Chemistry +10

Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite <i>Plasmodium falciparum</i> and Optimization Efforts

Claire Le Manach, Jean Dam, John G. Woodland et al. · Journal of Medicinal Chemistry · 2021 · 23 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Copper-imidazo[1,2-a]pyridines induce intrinsic apoptosis and modulate the expression of mutated p53, haem-oxygenase-1 and apoptotic inhibitory proteins in HT-29 colorectal cancer cells

Leonie Harmse, Nadia Gangat, Carla Martins-Furness et al. · APOPTOSIS · 2019 · 18 citations

Medicine, Oncology, Pharmacology +15

Identification of 2,4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and <i>In Vivo</i> Efficacy in the <i>Plasmodium falciparum</i> NSG Mouse Model

André Horatscheck, Ana Andrijević, Aloysius T. Nchinda et al. · Journal of Medicinal Chemistry · 2020 · 18 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Copper-imidazo[1,2-a]pyridines differentially modulate pro- and anti-apoptotic protein and gene expression in HL-60 and K562 leukaemic cells to cause apoptotic cell death

Zeenat Ismail, Jean Dam, Clement Penny et al. · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · 2021 · 11 citations

Life Sciences, Cell Biology, Molecular Biology +17