Niccolò Chiaramonte

2-Benzylpiperazine: A new scaffold for potent human carbonic anhydrase inhibitors. Synthesis, enzyme inhibition, enantioselectivity, computational and crystallographic studies and in vivo activity for a new class of intraocular pressure lowering agents

Niccolò Chiaramonte, Silvia Bua, Marta Ferraroni et al. · European Journal of Medicinal Chemistry · 2018 · 44 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Pharmaceutical Science +13

Modulation of the spacer in N,N-bis(alkanol)amine aryl ester heterodimers led to the discovery of a series of highly potent P-glycoprotein-based multidrug resistance (MDR) modulators

Silvia Dei, Laura Braconi, Alfonso Trezza et al. · European Journal of Medicinal Chemistry · 2019 · 28 citations · Full text

Medicinal Chemistry, Drug Resistance Analysis, Pharmaceutical Science +12

Sulfonamides incorporating piperazine bioisosteres as potent human carbonic anhydrase I, II, IV and IX inhibitors

Niccolò Chiaramonte, Silvia Bua, Andrea Angeli et al. · Bioorganic Chemistry · 2019 · 18 citations

Medicinal Chemistry, Pharmaceutical Science, Biochemistry +9

Design and synthesis of aminoester heterodimers containing flavone or chromone moieties as modulators of P-glycoprotein-based multidrug resistance (MDR)

Silvia Dei, María Novella Romanelli, Dina Manetti et al. · Bioorganic & Medicinal Chemistry · 2017 · 15 citations · Full text

Medicinal Chemistry, P-glycoprotein-based Multidrug Resistance, Bioorganic Chemistry +12

6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline amides and corresponding ester isosteres as multidrug resistance reversers

Laura Braconi, Gianluca Bartolucci, Marialessandra Contino et al. · Journal of Enzyme Inhibition and Medicinal Chemistry · 2020 · 14 citations · Full text