Alexandra C. Doolittle

TonEBP-deficiency accelerates intervertebral disc degeneration underscored by matrix remodeling, cytoskeletal rearrangements, and changes in proinflammatory gene expression

Steven Tessier, Victoria A. Tran, Olivia K. Ottone et al. · Matrix Biology · 2019 · 64 citations · Full text

Intervertebral Disc, Natural Sciences, Genetics +10

TNF-α promotes nuclear enrichment of the transcription factor TonEBP/NFAT5 to selectively control inflammatory but not osmoregulatory responses in nucleus pulposus cells

Zariel I. Johnson, Alexandra C. Doolittle, Joseph Snuggs et al. · Journal of Biological Chemistry · 2017 · 53 citations · Full text

Inflammation, Cytokine, Transcriptional Regulation +13

COX-2 expression mediated by calcium-TonEBP signaling axis under hyperosmotic conditions serves osmoprotective function in nucleus pulposus cells

Hyowon Choi, Weera Chaiyamongkol, Alexandra C. Doolittle et al. · Journal of Biological Chemistry · 2018 · 32 citations · Full text

Arp2/3 inactivation causes intervertebral disc and cartilage degeneration with dysregulated TonEBP-mediated osmoadaptation

Steven Tessier, Alexandra C. Doolittle, Kimheak Sao et al. · JCI Insight · 2020 · 28 citations · Full text

Intervertebral Disc, Cell Death, Cytoskeleton +17