CRISPR-mediated Genome Editing Restores Dystrophin Expression and Function in mdx Mice

Li Xu, Ki Ho Park, Lixia Zhao, +6

Molecular Therapy

Cidea promotes hepatic steatosis by sensing dietary fatty acids

Linkang Zhou, Li Xu, Jing Ye, +7

Hepatology

In Vivo Genome Editing Restores Dystrophin Expression and Cardiac Function in Dystrophic Mice

Mona El Refaey, Li Xu, Yandi Gao, +9

Circulation Research

The intracellular Ca2+ channel MCOLN1 is required for sarcolemma repair to prevent muscular dystrophy

Xiping Cheng, Xiaoli Zhang, Qiong Gao, +14

Nature Medicine

Molecular PhysiologySignal TransductionSkeletal MuscleSarcolemma RepairCellular Biochemistry +6

Insulin resistance and white adipose tissue inflammation are uncoupled in energetically challenged Fsp27-deficient mice

Linkang Zhou, Shi-Young Park, Li Xu, +18

Nature Communications

Differential Roles of Cell Death-inducing DNA Fragmentation Factor-α-like Effector (CIDE) Proteins in Promoting Lipid Droplet Fusion and Growth in Subpopulations of Hepatocytes

Wenyi Xu, Lizhen Wu, Miao Yu, +10

Journal of Biological Chemistry

Efficient precise in vivo base editing in adult dystrophic mice

Li Xu, Chen Zhang, Haiwen Li, +6

Nature Communications

Identification of the para-nitrophenol catabolic pathway, and characterization of three enzymes involved in the hydroquinone pathway, in pseudomonas sp. 1-7

Shuangyu Zhang, Wen Sun, Li Xu, +5

BMC Microbiology

Empower multiplex cell and tissue-specific CRISPR-mediated gene manipulation with self-cleaving ribozymes and tRNA

Li Xu, Lixia Zhao, Yandi Gao, +2

Nucleic Acids Research

Multiple Guide RnasOff-target EffectSelf-cleaving RibozymesNatural SciencesMolecular Biology +12

Cidea controls lipid droplet fusion and lipid storage in brown and white adipose tissue

Lizhen Wu, Linkang Zhou, Cheng Chen, +4

Science China Life Sciences