John F. Mehlmann

Design of amidobenzimidazole STING receptor agonists with systemic activity

Joshi M. Ramanjulu, G. Scott Pesiridis, Jingsong Yang et al. · Nature · 2018 · 803 citations

Systemic Activity, Medicine, Mechanism Of Action +4

The Identification and Pharmacological Characterization of 6-( <i>tert</i> -Butylsulfonyl)- <i>N</i> -(5-fluoro-1 <i>H</i> -indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase

Pamela A. Haile, Bartholomew J. Votta, Robert W. Marquis et al. · Journal of Medicinal Chemistry · 2016 · 122 citations · Full text

Regioselective Synthesis of Substituted Pyrroles:  Efficient Palladium-Catalyzed Cyclization of Internal Alkynes and 2-Amino-3-iodoacrylate Derivatives

Matthew L. Crawley, Igor Goljer, Douglas J. Jenkins et al. · Organic Letters · 2006 · 73 citations

Chemical Engineering, Engineering, Alkene Metathesis +10

Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2-((4-(Benzo[<i>d</i>]thiazol-5-ylamino)-6-(<i>tert</i>-butylsulfonyl)quinazolin-7-yl)oxy)ethyl Dihydrogen Phosphate, for the Treatment of Inflammatory Diseases

Pamela A. Haile, Linda Casillas, Bartholomew J. Votta et al. · Journal of Medicinal Chemistry · 2019 · 65 citations · Full text

Chronic Inflammatory Diseases, Drug Target, Immunology +25

Improvement of Physiochemical Properties of the Tetrahydroazepinoindole Series of Farnesoid X Receptor (FXR) Agonists: Beneficial Modulation of Lipids in Primates

Joseph T. Lundquist, Douglas C. Harnish, Callain Y. Kim et al. · Journal of Medicinal Chemistry · 2010 · 53 citations · Full text

Crystal Structure, Pharmaceutical Science, Farnesoid X Receptor +16