The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent

Rosellina Margherita Mancina, Paola Dongiovanni, Salvatore Petta, +22

Gastroenterology

Metabolic SyndromeHepatologyLiver PhysiologyGenetic EpidemiologyPathology +6

Causal relationship of hepatic fat with liver damage and insulin resistance in nonalcoholic fatty liver

Paola Dongiovanni, Stefan Stender, Alessandro Pietrelli, +17

Journal of Internal Medicine

PNPLA3 has retinyl-palmitate lipase activity in human hepatic stellate cells

Carlo Pirazzi, Luca Valenti, Benedetta Maria Motta, +19

Human Molecular Genetics

Fatty Liver DiseaseHuman HscsPnpla3 I148m GenotypePnpla3 Expression ResultsOxidative Stress +14

Recombinant PNPLA3 protein shows triglyceride hydrolase activity and its I148M mutation results in loss of function

Piero Pingitore, Carlo Pirazzi, Rosellina Margherita Mancina, +6

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

Pnpla3 silencing with antisense oligonucleotides ameliorates nonalcoholic steatohepatitis and fibrosis in Pnpla3 I148M knock-in mice

Daniel Lindén, Andrea Ahnmark, Piero Pingitore, +21

Molecular Metabolism

PNPLA3 overexpression results in reduction of proteins predisposing to fibrosis

Piero Pingitore, Paola Dongiovanni, Benedetta Maria Motta, +12

Human Molecular Genetics

Human Multilineage 3D Spheroids as a Model of Liver Steatosis and Fibrosis

Piero Pingitore, Kavitha Sasidharan, Matias Ekstrand, +3

International Journal of Molecular Sciences

The rs2294918 E434K variant modulates patatin‐like phospholipase domain‐containing 3 expression and liver damage

Benedetta Donati, Benedetta Maria Motta, Piero Pingitore, +15

Hepatology

The TM6SF2 E167K genetic variant induces lipid biosynthesis and reduces apolipoprotein B secretion in human hepatic 3D spheroids

Sebastian Prill, Andrea Caddeo, Guido Baselli, +15

Scientific Reports

GeneticsGenetic EpidemiologyPathologyFatty Liver DiseaseApob Particle Secretion +18

Liver transcriptomics highlights interleukin-32 as novel NAFLD-related cytokine and candidate biomarker

Guido Baselli, Paola Dongiovanni, Raffaela Rametta, +14

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