H Kitayama

Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product.

T Furitsu, Tohru Tsujimura, T. Tono et al. · Journal of Clinical Investigation · 1993 · 818 citations · Full text

Immunology, Signaling Pathway, Cell Regulation +16

Constitutively activating mutations of c-kit receptor tyrosine kinase confer factor-independent growth and tumorigenicity of factor-dependent hematopoietic cell lines

H Kitayama, Yuzuru Kanakura, T Furitsu et al. · Blood · 1995 · 287 citations

Detection of genes with a potential for suppressing the transformed phenotype associated with activated ras genes.

Makoto Noda, H Kitayama, Takao Matsuzaki et al. · Proceedings of the National Academy of Sciences · 1989 · 138 citations · Full text

Viral Replication, Reverse Genetics, Genetics +21

Neoplastic transformation of normal hematopoietic cells by constitutively activating mutations of c-kit receptor tyrosine kinase

H Kitayama, Tsuyoshi Tsujimura, Itaru Matsumura et al. · Blood · 1996 · 137 citations · Full text

Genetic analysis of the Kirsten-ras-revertant 1 gene: potentiation of its tumor suppressor activity by specific point mutations.

H Kitayama, Takao Matsuzaki, Yumi Ikawa et al. · Proceedings of the National Academy of Sciences · 1990 · 123 citations · Full text

Genetics, Immunology, Point Mutants +17