Emilia E. Savage

The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism

Denise Wootten, Christopher A. Reynolds, Kevin J. Smith et al. · Cell · 2016 · 161 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

Differential Activation and Modulation of the Glucagon-Like Peptide-1 Receptor by Small Molecule Ligands

Denise Wootten, Emilia E. Savage, Francis S. Willard et al. · Molecular Pharmacology · 2013 · 89 citations

Medicine, Endocrinology, Pharmacology +17

Allosteric Modulation of Endogenous Metabolites as an Avenue for Drug Discovery

Denise Wootten, Emilia E. Savage, Céline Valant et al. · Molecular Pharmacology · 2012 · 78 citations

Medicine, Medicinal Chemistry, Pharmacology +17

Small Molecule Allosteric Modulation of the Glucagon-Like Peptide-1 Receptor Enhances the Insulinotropic Effect of Oxyntomodulin

Francis S. Willard, Denise Wootten, Aaron D. Showalter et al. · Molecular Pharmacology · 2012 · 54 citations

Life Sciences, Medicinal Chemistry, Pharmacology +17

Second Extracellular Loop of Human Glucagon-like Peptide-1 Receptor (GLP-1R) Differentially Regulates Orthosteric but Not Allosteric Agonist Binding and Function

Cassandra Koole, Denise Wootten, John Simms et al. · Journal of Biological Chemistry · 2011 · 38 citations · Full text

Life Sciences, Pharmacology, Physiology +17